General transcriptional corepressor TUP1 (P16649)

Identification
NameGeneral transcriptional corepressor TUP1
Synonyms
  • Flocculation suppressor protein
  • Glucose repression regulatory protein TUP1
  • Repressor AER2
Gene NameTUP1
Enzyme ClassNot Available
Biological Properties
General Functiontranscription, DNA-templated
Specific FunctionActs as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
regulation of invasive growth in response to glucose limitation
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcriptional repressor complex
histone deacetylase binding
transcriptional repressor activity, RNA polymerase II transcription factor binding
negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
nucleosome positioning
regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
regulation of response to DNA damage stimulus
Elongator holoenzyme complex
histone acetyltransferase complex
transcription elongation factor complex
mediator complex binding
nucleus
phosphatidylinositol-3,5-bisphosphate binding
histone binding
histone exchange
negative regulation of transcription from RNA polymerase II promoter during mitosis
negative regulation of transcription from RNA polymerase II promoter by glucose
negative regulation of mating-type specific transcription from RNA polymerase II promoter
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2142 bp ATGACTGCCAGCGTTTCGAATACGCAGAATAAGCTGAATGAGCTTCTCGATGCCATCAGA CAGGAGTTTCTCCAAGTCTCACAAGAGGCAAATACCTACCGTCTTCAAAACCAAAAGGAT TACGATTTCAAAATGAACCAGCAGCTGGCTGAGATGCAGCAGATAAGAAACACCGTCTAC GAACTGGAACTAACTCACAGGAAAATGAAGGACGCGTACGAAGAAGAGATCAAGCACTTG AAACTAGGGCTGGAGCAAAGAGACCATCAAATTGCATCTTTGACCGTCCAGCAACAGCGG CAACAGCAACAGCAGCAACAGGTCCAGCAGCATTTACAACAGCAACAGCAGCAGCTAGCC GCTGCATCTGCATCTGTTCCAGTTGCGCAACAACCACCGGCTACTACTTCGGCCACCGCC ACTCCAGCAGCAAACACAACTACTGGTTCGCCATCGGCCTTCCCAGTACAAGCTAGCCGT CCTAATCTGGTTGGCTCACAGTTGCCTACCACCACTTTGCCTGTGGTGTCCTCAAACGCC CAACAACAACTACCACAACAGCAACTGCAACAGCAGCAACTTCAACAACAGCAACCACCT CCCCAGGTTTCCGTGGCACCATTGAGTAACACAGCCATCAACGGATCTCCTACTTCTAAA GAGACCACTACTTTACCCTCTGTCAAGGCACCTGAATCTACGTTGAAAGAAACTGAACCG GAAAATAATAATACCTCGAAGATAAATGACACCGGATCCGCCACCACGGCCACCACTACC ACCGCAACTGAAACTGAAATCAAACCTAAGGAGGAAGACGCCACCCCGGCTAGTTTGCAC CAGGATCACTACTTAGTCCCTTATAATCAAAGAGCAAACCACTCTAAACCTATCCCACCT TTCCTTTTGGATCTAGATTCCCAGTCTGTTCCCGATGCTCTGAAGAAGCAAACAAATGAT TATTATATTTTATACAACCCGGCACTACCAAGAGAAATTGACGTTGAGTTACACAAATCT TTGGATCATACTTCAGTTGTTTGTTGCGTGAAGTTCAGTAACGATGGTGAATACTTAGCC ACAGGCTGCAACAAAACTACTCAAGTGTATCGCGTTTCAGATGGTTCTCTGGTGGCCCGT CTATCTGACGATTCTGCTGCCAATAACCATCGAAATTCGATCACTGAAAATAACACCACC ACGTCCACGGATAACAATACAATGACAACCACTACTACCACCACAATTACTACCACAGCG ATGACTTCGGCAGCAGAATTGGCAAAAGATGTGGAAAACCTGAACACTTCGTCTTCCCCA TCATCCGACTTGTATATCCGTTCAGTGTGTTTTTCTCCAGATGGGAAATTTTTGGCAACA GGTGCTGAAGACAGACTGATTAGAATTTGGGATATTGAAAATAGAAAGATTGTTATGATT CTTCAAGGCCACGAACAAGATATTTATTCATTGGACTACTTTCCCTCAGGTGACAAATTA GTCTCCGGTTCTGGTGACCGTACCGTTCGTATTTGGGACTTACGTACAGGCCAGTGTTCA TTGACTTTATCCATTGAAGATGGTGTTACCACCGTCGCTGTATCACCAGGTGATGGTAAA TACATCGCTGCTGGTTCTCTAGATCGTGCTGTGAGAGTTTGGGATTCCGAGACCGGATTC TTGGTGGAAAGACTAGATTCGGAAAACGAATCCGGTACAGGCCACAAGGACTCTGTTTAT AGCGTTGTCTTCACTAGAGATGGACAAAGCGTTGTATCCGGCTCATTAGATAGATCTGTT AAGCTCTGGAATTTGCAGAATGCAAACAACAAGAGCGATTCGAAAACTCCAAATTCCGGC ACTTGTGAAGTTACGTATATCGGGCATAAAGACTTTGTATTGTCCGTGGCCACCACACAA AATGATGAGTACATCTTGTCCGGTTCCAAAGATCGTGGTGTCCTGTTTTGGGATAAGAAA TCCGGCAATCCGTTATTGATGTTGCAAGGTCATAGGAATTCAGTTATATCTGTGGCTGTG GCAAACGGGTCTCCGCTGGGTCCAGAATATAACGTTTTTGCTACTGGTAGCGGTGATTGT AAAGCAAGGATTTGGAAGTATAAAAAAATAGCGCCAAATTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues713
Protein Molecular Weight78307.17
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>General transcriptional corepressor TUP1 MTASVSNTQNKLNELLDAIRQEFLQVSQEANTYRLQNQKDYDFKMNQQLAEMQQIRNTVY ELELTHRKMKDAYEEEIKHLKLGLEQRDHQIASLTVQQQRQQQQQQQVQQHLQQQQQQLA AASASVPVAQQPPATTSATATPAANTTTGSPSAFPVQASRPNLVGSQLPTTTLPVVSSNA QQQLPQQQLQQQQLQQQQPPPQVSVAPLSNTAINGSPTSKETTTLPSVKAPESTLKETEP ENNNTSKINDTGSATTATTTTATETEIKPKEEDATPASLHQDHYLVPYNQRANHSKPIPP FLLDLDSQSVPDALKKQTNDYYILYNPALPREIDVELHKSLDHTSVVCCVKFSNDGEYLA TGCNKTTQVYRVSDGSLVARLSDDSAANNHRNSITENNTTTSTDNNTMTTTTTTTITTTA MTSAAELAKDVENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMI LQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGK YIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSV KLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKK SGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYKKIAPN
References
External Links
ResourceLink
Saccharomyces Genome Database TUP1
Uniprot IDP16649
Uniprot NameTUP1
PDB ID
1ERJ
General ReferenceNot Available