| Identification |
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| Name | Phenylalanyl-tRNA synthetase alpha chain |
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| Synonyms | - Phenylalanine--tRNA ligase alpha chain
- PheRS
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| Gene Name | FRS2 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in nucleotide binding |
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| Specific Function | ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe) |
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| Cellular Location | Cytoplasm |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00097 | Adenosine monophosphate | Show | | YMDB00109 | Adenosine triphosphate | Show | | YMDB00219 | Pyrophosphate | Show | | YMDB00304 | L-Phenylalanine | Show |
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| GO Classification | | Component |
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| cell part | | intracellular part | | cytoplasm | | Function |
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| nucleic acid binding | | adenyl nucleotide binding | | RNA binding | | adenyl ribonucleotide binding | | tRNA binding | | ATP binding | | phenylalanine-tRNA ligase activity | | ligase activity, forming carbon-oxygen bonds | | ligase activity, forming aminoacyl-tRNA and related compounds | | catalytic activity | | aminoacyl-tRNA ligase activity | | nucleotide binding | | ligase activity | | binding | | nucleoside binding | | purine nucleoside binding | | Process |
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| phenylalanyl-tRNA aminoacylation | | metabolic process | | macromolecule metabolic process | | cellular macromolecule metabolic process | | RNA metabolic process | | ncRNA metabolic process | | biosynthetic process | | tRNA metabolic process | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | macromolecule biosynthetic process | | cellular macromolecule biosynthetic process | | translation |
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| Gene Properties |
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| Chromosome Location | chromosome 6 |
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| Locus | YFL022C |
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| Gene Sequence | >1512 bp
ATGTCTGATTTCCAATTAGAAATTCTAAAAAAACTAGATGAATTGGATGAGATCAAGTCC
ACACTGGCAACTTTCCCTCAGCACGGCTCTCAAGATGTTCTTTCCGCTTTGAACTCTTTG
AAAGCCCACAACAAGTTAGAGTTTTCCAAGGTCGACACGGTTACGTATGACTTGACCAAA
GAAGGTGCTCAAATTTTGAATGAAGGTTCGTACGAAATTAAACTAGTCAAGCTCATCCAA
GAGTTGGGTCAACTTCAAATCAAAGATGTGATGTCCAAACTGGGTCCTCAAGTTGGTAAG
GTCGGTCAGGCTAGAGCTTTCAAGAACGGCTGGATCGCCAAAAACGCCTCAAACGAGCTT
GAACTCTCCGCAAAATTGCAAAATACCGATTTAAATGAGCTTACTGATGAAACGCAATCT
ATTCTAGCGCAAATCAAGAACAACTCGCATCTGGATAGCATTGACGCCAAGATTTTGAAC
GACTTGAAGAAAAGAAAGTTAATTGCTCAAGGTAAAATCACAGATTTCAACGTTACCAAA
GGGCCAGAGTTCTCGACCGACCTCACCAAATTGGAAACCGATCTTACCTCCGACATGGTC
TCCACCAATGCATACAAGGACTTGAAGTTCAAGCCTTACAATTTCAATTCTCAAGGTGTG
CAAATATCTTCAGGTGCTCTTCACCCCTTAAACAAAGTCAGAGAGGAATTTAGACAAATT
TTCTTTTCCATGGGATTCACAGAGATGCCCTCGAACCAATACGTCGAGACAGGTTTCTGG
AACTTCGATGCCCTTTACGTCCCACAACAGCATCCTGCTCGTGACCTGCAAGACACTTTC
TACATCAAGGACCCACTAACCGCTGACTTGCCCGATGACAAGACATACATGGACAATATC
AAAGCCGTTCACGAACAGGGGAGATTCGGGTCCATCGGTTATCGTTACAACTGGAAGCCA
GAAGAATGTCAAAAATTGGTCTTGAGAACTCACTCCACAGCCATCTCTGCCAGAATGCTG
CACGATTTGGCCAAAGATCCAAAGCCCACCAGATTGTTTTCTATCGACCGTGTTTTCCGT
AACGAAGCAGTTGACGCCACCCATTTGGCCGAATTCCACCAGGTGGAAGGTGTTCTTGCC
GACTACAACATTACTCTGGGTGACCTGATCAAGTTCATGGAAGAGTTTTTCGAAAGAATG
GGTGTCACCGGTTTGAGATTCAAGCCTACCTACAATCCTTACACCGAGCCATCAATGGAA
ATCTTTTCTTGGCACGAAGGTTTGCAAAAATGGGTCGAAATCGGTAACTCTGGTATGTTC
AGACCAGAAATGCTCGAGTCCATGGGTCTACCAAAGGATCTAAGAGTCCTTGGTTGGGGG
TTATCCTTGGAAAGACCTACCATGATCAAATATAAGGTTCAAAACATCAGAGAACTGTTA
GGTCATAAAGTCTCTTTGGACTTTATCGAAACCAATCCTGCTGCTAGATTGGACGAAGAC
TTGTACGAATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 503 |
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| Protein Molecular Weight | 57511.0 |
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| Protein Theoretical pI | 5.53 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Phenylalanyl-tRNA synthetase alpha chain
MSDFQLEILKKLDELDEIKSTLATFPQHGSQDVLSALNSLKAHNKLEFSKVDTVTYDLTK
EGAQILNEGSYEIKLVKLIQELGQLQIKDVMSKLGPQVGKVGQARAFKNGWIAKNASNEL
ELSAKLQNTDLNELTDETQSILAQIKNNSHLDSIDAKILNDLKKRKLIAQGKITDFNVTK
GPEFSTDLTKLETDLTSDMVSTNAYKDLKFKPYNFNSQGVQISSGALHPLNKVREEFRQI
FFSMGFTEMPSNQYVETGFWNFDALYVPQQHPARDLQDTFYIKDPLTADLPDDKTYMDNI
KAVHEQGRFGSIGYRYNWKPEECQKLVLRTHSTAISARMLHDLAKDPKPTRLFSIDRVFR
NEAVDATHLAEFHQVEGVLADYNITLGDLIKFMEEFFERMGVTGLRFKPTYNPYTEPSME
IFSWHEGLQKWVEIGNSGMFRPEMLESMGLPKDLRVLGWGLSLERPTMIKYKVQNIRELL
GHKVSLDFIETNPAARLDEDLYE |
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| References |
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| External Links | |
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| General Reference | - Sanni, A., Mirande, M., Ebel, J. P., Boulanger, Y., Waller, J. P., Fasiolo, F. (1988). "Structure and expression of the genes encoding the alpha and beta subunits of yeast phenylalanyl-tRNA synthetase." J Biol Chem 263:15407-15415.3049607
- Murakami, Y., Naitou, M., Hagiwara, H., Shibata, T., Ozawa, M., Sasanuma, S., Sasanuma, M., Tsuchiya, Y., Soeda, E., Yokoyama, K., et, a. l. .. (1995). "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Nat Genet 10:261-268.7670463
- Fasiolo, F., Sanni, A., Potier, S., Ebel, J. P., Boulanger, Y. (1989). "Identification of the major tRNA(Phe) binding domain in the tetrameric structure of cytoplasmic phenylalanyl-tRNA synthetase from baker's yeast." FEBS Lett 242:351-356.2644133
- Garrels, J. I., McLaughlin, C. S., Warner, J. R., Futcher, B., Latter, G. I., Kobayashi, R., Schwender, B., Volpe, T., Anderson, D. S., Mesquita-Fuentes, R., Payne, W. E. (1997). "Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins." Electrophoresis 18:1347-1360.9298649
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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