Orotate phosphoribosyltransferase 1 (P13298)

Identification
NameOrotate phosphoribosyltransferase 1
Synonyms
  • OPRT 1
  • OPRTase 1
Gene NameURA5
Enzyme Class
Biological Properties
General FunctionInvolved in orotate phosphoribosyltransferase activity
Specific FunctionCatalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Cellular LocationNot Available
SMPDB Pathways
Pyrimidine metabolismPW002469 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Pyrimidine metabolismec00240 Map00240
SMPDB ReactionsNot Available
KEGG Reactions
Pyrophosphate + Orotidylic acid ↔ Orotic acid + Phosphoribosyl pyrophosphate
Metabolites
YMDB IDNameView
YMDB00025Orotidylic acidShow
YMDB00219PyrophosphateShow
YMDB00402Phosphoribosyl pyrophosphateShow
YMDB00405Orotic acidShow
GO Classification
Component
Not Available
Function
transferase activity, transferring pentosyl groups
orotate phosphoribosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine nucleotide metabolic process
pyrimidine nucleotide biosynthetic process
nucleoside metabolic process
Gene Properties
Chromosome Locationchromosome 13
LocusYML106W
Gene Sequence>681 bp ATGCCTATTATGTTGGAAGACTACCAAAAGAACTTTCTAGAGTTGGCCATCGAATGCCAG GCTCTAAGATTTGGTTCATTCAAGTTGAAATCAGGTAGAGAATCGCCATATTTCTTTAAT TTGGGATTGTTCAATACTGGTAAATTGCTTTCCAATTTGGCTACTGCGTATGCAATTGCC ATCATACAATCTGATTTGAAATTTGATGTGATTTTCGGTCCTGCCTACAAAGGTATCCCA CTTGCTGCTATTGTTTGTGTGAAATTGGCGGAGATTGGTGGCTCTAAATTTCAAAACATT CAGTACGCTTTTAACAGAAAGGAAGCCAAAGATCATGGTGAAGGTGGTATCATTGTCGGC TCTGCCCTAGAGAACAAGAGAATATTAATCATCGACGACGTCATGACTGCTGGTACTGCC ATTAACGAGGCCTTTGAGATCATCAGTAACGCCAAGGGTCAGGTAGTTGGCTCCATAATT GCTCTTGATAGACAGGAAGTTGTGAGTACTGACGATAAAGAAGGACTCAGCGCCACTCAA ACTGTTAGCAAAAAATACGGTATCCCAGTCTTGAGCATTGTCTCCTTAATTCACATAATT ACCTATTTGGAAGGCAGAATAACAGCAGAAGAGAAAAGCAAGATCGAACAATACCTTCAA ACCTACGGTGCCTCCGCTTAA
Protein Properties
Pfam Domain Function
Protein Residues226
Protein Molecular Weight24664.19922
Protein Theoretical pI5.85
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Orotate phosphoribosyltransferase 1 MPIMLEDYQKNFLELAIECQALRFGSFKLKSGRESPYFFNLGLFNTGKLLSNLATAYAIA IIQSDLKFDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVG SALENKRILIIDDVMTAGTAINEAFEIISNAKGQVVGSIIALDRQEVVSTDDKEGLSATQ TVSKKYGIPVLSIVSLIHIITYLEGRITAEEKSKIEQYLQTYGASA
References
External Links
ResourceLink
Saccharomyces Genome Database URA5
Uniprot IDP13298
Uniprot NamePYRE_YEAST
GenBank Gene IDAY693160
Genebank Protein ID51013771
General Reference
  • de Montigny, J., Belarbi, A., Hubert, J. C., Lacroute, F. (1989). "Structure and expression of the URA5 gene of Saccharomyces cerevisiae." Mol Gen Genet 215:455-462.2651891
  • Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106