Pheromone receptor transcription factor (P11746)

Identification
NamePheromone receptor transcription factor
Synonyms
  • GRM/PRTF protein
Gene NameMCM1
Enzyme ClassNot Available
Biological Properties
General Functionregulation of mating type switching
Specific FunctionTranscription factor required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes. Activates transcription of ECB-dependent genes during the G1/M phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes. With ARG80, ARG81 and ARG82, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
DNA replication origin binding
regulation of mating type switching
RNA polymerase II activating transcription factor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
arginine metabolic process
DNA replication initiation
negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter
negative regulation of mating-type specific transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
cytosol
positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
nucleus
positive regulation of mating-type specific transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
nuclear chromatin
positive regulation of transcription involved in G2/M transition of mitotic cell cycle
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>861 bp ATGTCAGACATCGAAGAAGGTACGCCTACTAATAATGGGCAACAGAAGGAGAGAAGAAAG ATAGAAATTAAGTTCATCGAGAATAAAACAAGGCGCCATGTGACATTTTCCAAAAGGAAG CACGGTATCATGAAAAAGGCGTTTGAGCTTTCTGTTCTAACGGGGACCCAGGTCCTGTTG CTAGTCGTTTCAGAAACAGGTTTGGTATATACTTTCAGCACGCCGAAGTTTGAACCTATA GTCACGCAGCAGGAAGGTAGAAACCTGATCCAGGCCTGTCTTAACGCCCCTGATGATGAG GAAGAAGACGAGGAGGAAGACGGTGATGATGATGATGATGATGACGATGATGGTAATGAT ATGCAACGCCAGCAACCACAACAACAGCAACCGCAACAACAGCAACAAGTATTGAATGCA CACGCAAATAGCTTAGGCCATCTAAATCAAGATCAGGTACCGGCAGGCGCGCTGAAACAA GAGGTGAAGTCACAATTGCTAGGCGGTGCCAATCCTAATCAAAACTCAATGATTCAACAG CAGCAACATCACACGCAGAATTCACAACCACAACAGCAACAGCAACAACAACCACAGCAG CAAATGTCACAGCAACAAATGTCACAGCATCCTCGACCACAGCAAGGAATACCACATCCG CAACAATCGCAGCCACAGCAACAGCAACAACAACAACAACAACTGCAACAGCAGCAACAG CAGCAACAACAACAACCCCTCACCGGCATTCATCAGCCTCACCAACAGGCTTTTGCCAAC GCTGCCTCCCCCTATCTGAATGCTGAACAGAATGCTGCCTACCAACAATACTTTCAAGAA CCGCAACAAGGCCAATACTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues286
Protein Molecular Weight32801.685
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Pheromone receptor transcription factor MSDIEEGTPTNNGQQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLL LVVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDEEEDGDDDDDDDDDGND MQRQQPQQQQPQQQQQVLNAHANSLGHLNQDQVPAGALKQEVKSQLLGGANPNQNSMIQQ QQHHTQNSQPQQQQQQQPQQQMSQQQMSQHPRPQQGIPHPQQSQPQQQQQQQQQLQQQQQ QQQQQPLTGIHQPHQQAFANAASPYLNAEQNAAYQQYFQEPQQGQY
References
External Links
ResourceLink
Saccharomyces Genome Database MCM1
Uniprot IDP11746
Uniprot NameMCM1
PDB ID
1MNM
General ReferenceNot Available