Cytochrome b-c1 complex subunit 8 (P08525)

Identification
NameCytochrome b-c1 complex subunit 8
Synonyms
  • Complex III subunit 8
  • Complex III subunit VII
  • Ubiquinol-cytochrome c reductase complex 11 kDa protein
  • Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene NameQCR8
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in ubiquinol-cytochrome-c reductase activity
Specific FunctionComponent of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR8, together with cytochrome b, binds to ubiquinone
Cellular LocationMitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
ubiquinol-cytochrome-c reductase activity
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>285 bp ATGGGTCCTCCAAGCGGTAAAACTTACATGGGATGGTGGGGTCACATGGGTGGTCCAAAG CAAAAAGGTATAACCTCATATGCTGTGTCTCCATATGCTCAAAAGCCATTACAAGGTATT TTCCATAACGCTGTATTCAATAGTTTTAGAAGATTTAAGTCTCAATTTCTATATGTATTA ATACCTGCGGGAATTTATTGGTACTGGTGGAAGAACGGTAACGAGTATAATGAATTTCTG TACAGCAAAGCTGGTAGAGAAGAGCTGGAAAGAGTTAATGTTTAA
Protein Properties
Pfam Domain Function
Protein Residues94
Protein Molecular Weight10974.5
Protein Theoretical pI10.08
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Cytochrome b-c1 complex subunit 8 MGPPSGKTYMGWWGHMGGPKQKGITSYAVSPYAQKPLQGIFHNAVFNSFRRFKSQFLYVL IPAGIYWYWWKNGNEYNEFLYSKAGREELERVNV
References
External Links
ResourceLink
Saccharomyces Genome Database QCR8
Uniprot IDP08525
Uniprot NameQCR8_YEAST
GenBank Gene IDAY558554
Genebank Protein ID45270998
PDB ID
1P84
General Reference
  • Maarse, A. C., Grivell, L. A. (1987). "Nucleotide sequence of the gene encoding the 11-kDa subunit of the ubiquinol-cytochrome-c oxidoreductase in Saccharomyces cerevisiae." Eur J Biochem 165:419-425.3036507
  • Hemrika, W., Berden, J. A., Grivell, L. A. (1993). "A region of the C-terminal part of the 11-kDa subunit of ubiquinol-cytochrome-c oxidoreductase of the yeast Saccharomyces cerevisiae contributes to the structure of the Qout reaction domain." Eur J Biochem 215:601-609.8394810
  • Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Hunte, C., Koepke, J., Lange, C., Rossmanith, T., Michel, H. (2000). "Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment." Structure 8:669-684.10873857
  • Lange, C., Hunte, C. (2002). "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c." Proc Natl Acad Sci U S A 99:2800-2805.11880631