| Identification |
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| Name | Inositol polyphosphate multikinase |
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| Synonyms | - IPMK
- Arginine metabolism regulation protein III
|
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| Gene Name | ARG82 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in inositol trisphosphate 3-kinase activity |
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| Specific Function | Has kinase activity and phosphorylates inositol-1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. Originally it was proposed that the ARGRI and ARGRIII proteins are more likely to be involved in the control of ARGRII activity |
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| Cellular Location | Not Available |
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| SMPDB Pathways | |
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| KEGG Pathways | | Inositol phosphate metabolism | ec00562 |  |
|
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| SMPDB Reactions |
|
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| KEGG Reactions | | Adenosine triphosphate
+
hydron
+
1D-Myo-Inositol 1,3,4,5-tetrakisphosphate
→
ADP
+
Inositol 1,3,4,5,6-pentakisphosphate
| | Adenosine triphosphate
+
hydron
+
1D-Myo-inositol 1,4,5,6-tetrakisphosphate
→
ADP
+
Inositol 1,3,4,5,6-pentakisphosphate
| | Adenosine triphosphate
+
hydron
+
Inositol 1,4,5-trisphosphate
→
1D-Myo-inositol 1,4,5,6-tetrakisphosphate
+
ADP
| | Adenosine triphosphate
+
hydron
+
Inositol 1,4,5-trisphosphate
→
1D-Myo-Inositol 1,3,4,5-tetrakisphosphate
+
ADP
|
|
|---|
| Metabolites | | YMDB ID | Name | View |
|---|
| YMDB00006 | 1D-Myo-inositol 1,4,5,6-tetrakisphosphate | Show | | YMDB00013 | 5-Diphosphoinositol pentakisphosphate | Show | | YMDB00109 | Adenosine triphosphate | Show | | YMDB00291 | Inositol 1,4,5-trisphosphate | Show | | YMDB00500 | Myo-Inositol hexakisphosphate | Show | | YMDB00711 | 1D-Myo-Inositol 1,3,4,5-tetrakisphosphate | Show | | YMDB00764 | 1D-myo-inositol 4,5-bisphosphate | Show | | YMDB00862 | hydron | Show | | YMDB00914 | ADP | Show | | YMDB00946 | Inositol 1,3,4,5,6-pentakisphosphate | Show | | YMDB16241 | 1-Diphosinositol pentakisphosphate | Show | | YMDB16333 | 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate | Show | | YMDB16334 | 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate | Show | | YMDB16335 | 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate | Show |
|
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| GO Classification | | Component |
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| Not Available | | Function |
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| catalytic activity | | transferase activity | | transferase activity, transferring phosphorus-containing groups | | kinase activity | | inositol or phosphatidylinositol kinase activity | | inositol trisphosphate kinase activity | | inositol trisphosphate 3-kinase activity | | Process |
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| Not Available |
|
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| Gene Properties |
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| Chromosome Location | chromosome 4 |
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| Locus | YDR173C |
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| Gene Sequence | >1068 bp
ATGGATACGGTAAACAATTATAGGGTTTTAGAGCATAAAGCTGCTGGCCACGACGGTACT
CTAACAGACGGTGATGGATTGCTCATCTTTAAACCGGCCTTTCCGCAGGAACTGGAATTC
TACAAAGCCATACAAGTGAGAGATGTGAGTCGAAGAAAGTCTTCGGCTGATGGAGATGCT
CCCTTGTGCTCTTGGATGCCCACGTATCTTGGAGTCTTGAATGAAGGGGCAAAAATCGAG
CAAAGTGGCGATGCTGCGCTTCTGAAGATAGATGAGCGGTTAAGTGATTCCACTGATAAT
CTTGATTCAATACCTGTAAAGTCTGAGAAGTCCAAGCAATACCTCGTTTTAGAAAATCTA
CTATATGGATTTAGTAAACCTAATATACTTGATATAAAATTAGGCAAAACTTTGTATGAT
TCGAAGGCATCATTGGAAAAAAGAGAGAGAATGAAAAGAGTCAGTGAGACGACGACTTCA
GGATCTTTGGGTTTCAGGATATGTGGCATGAAAATACAGAAAAATCCCTCTGTGCTGAAT
CAGCTTTCGCTCGAATATTACGAAGAAGAAGCAGACAGTGATTATATCTTTATAAACAAA
TTGTATGGTCGTTCAAGAACCGATCAAAATGTTTCAGATGCAATTGAACTTTATTTTAAC
AATCCTCATCTGTCGGATGCGAGAAAGCATCAACTGAAGAAAACATTTTTGAAAAGATTG
CAGTTGTTTTATAATACTATGCTAGAAGAAGAAGTTAGAATGATATCAAGTAGTCTTTTG
TTTATTTACGAAGGAGACCCGGAGCGATGGGAATTACTAAATGATGTTGACAAACTTATG
CGAGATGATTTTATAGACGATGATGACGACGATGATGATAATGATGATGATGATGATGAT
GATGCCGAGGGAAGCAGCGAAGGACCAAAGGACAAAAAAACAACTGGTTCTTTGAGTTCC
ATGTCACTAATAGATTTTGCACATTCTGAAATAACGCCGGGGAAGGGTTATGATGAAAAC
GTGATTGAAGGAGTTGAAACCTTGCTAGATATTTTTATGAAATTCTAG |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 355 |
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| Protein Molecular Weight | 40352.5 |
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| Protein Theoretical pI | 4.33 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Inositol polyphosphate multikinase
MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDA
PLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENL
LYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLN
QLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRL
QLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDD
DAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF |
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| References |
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| External Links | |
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| General Reference | - Dubois, E., Bercy, J., Messenguy, F. (1987). "Characterization of two genes, ARGRI and ARGRIII required for specific regulation of arginine metabolism in yeast." Mol Gen Genet 207:142-148.3298999
- Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
- Saiardi, A., Erdjument-Bromage, H., Snowman, A. M., Tempst, P., Snyder, S. H. (1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases." Curr Biol 9:1323-1326.10574768
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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