Histidine permease (P06775)

Identification
NameHistidine permease
SynonymsNot Available
Gene NameHIP1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transport
Specific FunctionHigh-affinity permease for histidine
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00369L-HistidineShow
YMDB00862hydronShow
GO Classification
Component
cell part
membrane
membrane part
intrinsic to membrane
integral to membrane
Function
amino acid transmembrane transporter activity
transporter activity
transmembrane transporter activity
active transmembrane transporter activity
amine transmembrane transporter activity
Process
amine transport
amino acid transport
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 7
LocusYGR191W
Gene Sequence>1812 bp ATGCCTAGAAACCCATTGAAAAAGGAATATTGGGCAGATGTAGTTGACGGATTCAAGCCG GCTACTTCTCCAGCCTTCGAGAATGAAAAAGAATCTACTACATTTGTTACCGAACTAACT TCCAAAACCGATTCTGCATTTCCATTAAGTAGCAAGGATTCACCTGGCATAAACCAAACC ACAAACGATATTACCTCTTCAGATCGCTTCCGTCGTAATGAAGACACAGAGCAGGAAGAC ATCAACAACACCAACCTGAGTAAAGATCTATCCGTGAGACATCTTTTAACTCTAGCTGTC GGGGGTGCAATAGGTACTGGTTTATATGTGAATACGGGTGCTGCTTTATCTACAGGTGGT CCGGCCAGTTTAGTTATTGATTGGGTTATTATCAGTACATGTCTTTTTACTGTGATTAAC TCTCTTGGTGAGCTGTCCGCTGCTTTTCCCGTTGTTGGTGGGTTCAATGTTTACAGTATG CGTTTTATTGAGCCTTCATTTGCATTCGCAGTGAACTTAAACTATTTAGCACAATGGCTA GTTCTTCTACCCTTGGAATTAGTGGCCGCATCTATTACTATAAAATACTGGAATGATAAA ATTAATTCCGACGCCTGGGTTGCTATCTTTTATGCCACCATTGCACTGGCTAATATGTTG GATGTTAAGTCATTTGGTGAGACCGAATTTGTATTGTCCATGATTAAAATCCTCTCCATC ATTGGCTTTACTATCTTAGGTATTGTTTTGTCCTGTGGTGGTGGGCCTCACGGCGGTTAC ATTGGTGGTAAATACTGGCATGACCCAGGCGCTTTTGTAGGGCACAGCTCGGGAACTCAG TTTAAAGGTTTATGTTCAGTTTTTGTTACCGCTGCCTTTTCTTATTCCGGTATTGAAATG ACTGCTGTCTCCGCTGCTGAAAGTAAAAATCCAAGAGAAACCATTCCCAAGGCAGCAAAG AGAACTTTTTGGCTGATTACCGCCTCTTATGTGACTATATTGACTTTGATTGGTTGCTTG GTTCCATCCAATGACCCTAGGTTACTAAACGGTTCAAGTTCAGTGGACGCTGCCTCATCT CCTCTGGTTATCGCAATTGAAAACGGGGGTATTAAAGGTCTACCATCATTAATGAACGCC ATTATTTTGATTGCTGTTGTTTCCGTGGCTAACAGTGCTGTTTATGCATGTTCAAGGTGT ATGGTCGCCATGGCTCATATTGGTAATTTACCAAAATTTTTGAACCGTGTTGACAAAAGG GGTAGACCAATGAATGCTATCTTGTTAACTTTGTTTTTTGGTTTGCTTTCCTTTGTGGCA GCAAGTGATAAGCAAGCTGAAGTCTTTACATGGTTGAGTGCCTTATCTGGTTTATCGACA ATTTTCTGCTGGATGGCCATTAATCTTTCCCATATTAGATTTCGCCAAGCCATGAAAGTT CAAGAAAGGTCTTTAGACGAATTACCCTTCATTTCTCAAACTGGCGTCAAGGGATCCTGG TATGGTTTTATCGTTTTATTTCTGGTTCTTATAGCATCGTTTTGGACTTCTCTGTTCCCA TTAGGCGGTTCAGGAGCCAGCGCAGAATCATTCTTTGAAGGATACTTATCCTTTCCAATT TTGATTGTCTGTTACGTTGGACATAAACTGTATACTAGAAATTGGACTTTGATGGTGAAA CTAGAAGATATGGATCTTGATACCGGCAGAAAACAAGTAGATTTGACTCTTCGTAGGGAA GAAATGAGGATTGAGCGAGAAACATTAGCAAAAAGATCCTTCGTAACAAGATTTTTACAT TTCTGGTGTTGA
Protein Properties
Pfam Domain Function
Protein Residues603
Protein Molecular Weight66005.60156
Protein Theoretical pI7.44
Signalling Regions
  • None
Transmembrane Regions
  • 96-116
  • 122-142
  • 166-185
  • 204-223
  • 237-255
  • 280-297
  • 322-342
  • 377-396
  • 424-442
  • 452-472
  • 492-510
  • 531-549
Protein Sequence>Histidine permease MPRNPLKKEYWADVVDGFKPATSPAFENEKESTTFVTELTSKTDSAFPLSSKDSPGINQT TNDITSSDRFRRNEDTEQEDINNTNLSKDLSVRHLLTLAVGGAIGTGLYVNTGAALSTGG PASLVIDWVIISTCLFTVINSLGELSAAFPVVGGFNVYSMRFIEPSFAFAVNLNYLAQWL VLLPLELVAASITIKYWNDKINSDAWVAIFYATIALANMLDVKSFGETEFVLSMIKILSI IGFTILGIVLSCGGGPHGGYIGGKYWHDPGAFVGHSSGTQFKGLCSVFVTAAFSYSGIEM TAVSAAESKNPRETIPKAAKRTFWLITASYVTILTLIGCLVPSNDPRLLNGSSSVDAASS PLVIAIENGGIKGLPSLMNAIILIAVVSVANSAVYACSRCMVAMAHIGNLPKFLNRVDKR GRPMNAILLTLFFGLLSFVAASDKQAEVFTWLSALSGLSTIFCWMAINLSHIRFRQAMKV QERSLDELPFISQTGVKGSWYGFIVLFLVLIASFWTSLFPLGGSGASAESFFEGYLSFPI LIVCYVGHKLYTRNWTLMVKLEDMDLDTGRKQVDLTLRREEMRIERETLAKRSFVTRFLH FWC
References
External Links
ResourceLink
Saccharomyces Genome Database HIP1
Uniprot IDP06775
Uniprot NameHIP1_YEAST
GenBank Gene IDM11980
Genebank Protein ID553131
General Reference
  • Tanaka, J., Fink, G. R. (1985). "The histidine permease gene (HIP1) of Saccharomyces cerevisiae." Gene 38:205-214.3905514
  • Arroyo, J., Garcia-Gonzalez, M., Garcia-Saez, M. I., Sanchez, M., Nombela, C. (1995). "The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII." Yeast 11:587-591.7645350
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258