Uroporphyrinogen-III synthase (P06174)

Identification
NameUroporphyrinogen-III synthase
Synonyms
  • UROIIIS
  • UROS
  • Hydroxymethylbilane hydrolyase [cyclizing]
  • Uroporphyrinogen-III cosynthase
Gene NameHEM4
Enzyme Class
Biological Properties
General FunctionInvolved in uroporphyrinogen-III synthase activity
Specific FunctionCatalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG Pathways
Porphyrin and chlorophyll metabolismec00860 Map00860
SMPDB ReactionsNot Available
KEGG Reactions
Hydroxymethylbilane → Uroporphyrinogen III + water
Metabolites
YMDB IDNameView
YMDB00145HydroxymethylbilaneShow
YMDB00267Uroporphyrinogen IIIShow
YMDB00890waterShow
GO Classification
Component
Not Available
Function
carbon-oxygen lyase activity
hydro-lyase activity
uroporphyrinogen-III synthase activity
catalytic activity
lyase activity
Process
metabolic process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
tetrapyrrole biosynthetic process
Gene Properties
Chromosome Locationchromosome 15
LocusYOR278W
Gene Sequence>828 bp ATGTCTAGTCGTAAAAAAGTCAGAGTATTACTGCTCAAGAATAAAACTGTCCCCATTGAT AAATATGAATTGGAGTGTAGGAGTAAGGCGTTTGAACCCATATTCGTACCGCTTATTAAA CATACACATGTAATTCAAGATTTTAGAAATGTTTTGAATACCATCCCAAACTATTTGAAT ACTATCAATTACATTATTATTACCTCTCAAAGGACTGTAGAGTCATTGAATGAAGCGATC ATTCCCACATTGACAAGTGAACAAAAAGCTGCATTGCTCAGTAAAACAGTTTATACTGTA GGCCCTGCTACTGCTAACTTCATCAGAAGATCAGGTTTCATTAATGTTAAAGGTGGAGAA GACGCTGGTAATGGTTCAATCCTTGCTGATATAATTATTGATGACTTGAGTACGGATATT AAGGCATGCCCACCAAGTGAACTATTATTTCTCGTGGGTGAAATTAGAAGAGATATCATC CCAAAGAAACTCCATAGCAAGGGAATAAAAGTAAGAGAAGTGGTTACTTATAAAACTGAA GAATTAAGCGACGGTTTTAAAAGATTCATACACGCCATGAAAGAATGCGATGAGGATGAA GTATTCTCGGACTGGGTGGTAGTTTTCAGTCCCCAGGGAACGAAAGAAATTACTCAGTAT TTGGGTGACAGTAACCGCCTACCAGGTTCCCATCTACGGGTTGCGTCCATCGGACCTACC ACTAAAAAATATCTGGATGATAATGATGTAACCTCTGATGTGGTCAGTCCAAAACCGGAC CCCAAGTCGCTATTAGATGCTATTGAATTATACCAGCGCCATAAATAA
Protein Properties
Pfam Domain Function
Protein Residues275
Protein Molecular Weight30911.30078
Protein Theoretical pI8.44
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Uroporphyrinogen-III synthase MSSRKKVRVLLLKNKTVPIDKYELECRSKAFEPIFVPLIKHTHVIQDFRNVLNTIPNYLN TINYIIITSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGE DAGNGSILADIIIDDLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTE ELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGDSNRLPGSHLRVASIGPT TKKYLDDNDVTSDVVSPKPDPKSLLDAIELYQRHK
References
External Links
ResourceLink
Saccharomyces Genome Database HEM4
Uniprot IDP06174
Uniprot NameHEM4_YEAST
GenBank Gene IDX89633
Genebank Protein ID1279703
General Reference
  • Langgut, W., Entrup, R., Schweizer, E. (1986). "Isolation of a nuclear yeast gene involved in the mitochondrial import of cytoplasmically synthesized precursor proteins." Curr Genet 11:177-184.2834088
  • Cheret, G., Bernardi, A., Sor, F. (1996). "DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae." Yeast 12:1059-1064.8896271
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Amillet, J. M., Labbe-Bois, R. (1995). "Isolation of the gene HEM4 encoding uroporphyrinogen III synthase in Saccharomyces cerevisiae." Yeast 11:419-424.7597845
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106