Identification
NameUracil permease
SynonymsNot Available
Gene NameFUR4
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in nucleobase transmembrane transporter activity
Specific FunctionTransport of uracil
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00098UracilShow
YMDB00862hydronShow
GO Classification
Component
cell part
membrane
Function
substrate-specific transmembrane transporter activity
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity
nucleobase transmembrane transporter activity
transporter activity
transmembrane transporter activity
Process
establishment of localization
transport
nucleobase, nucleoside, nucleotide and nucleic acid transport
transmembrane transport
Gene Properties
Chromosome Locationchromosome 2
LocusYBR021W
Gene Sequence>1902 bp ATGCCAGACAATCTATCATTACATTTAAGCGGCTCTTCAAAAAGATTGAACTCTCGCCAA CTTATGGAATCTTCCAATGAGACCTTTGCGCCAAATAATGTGGATTTGGAAAAAGAGTAT AAGTCATCTCAGAGTAATATAACTACCGAAGTTTATGAGGCATCGAGCTTTGAAGAAAAA GTAAGCTCAGAAAAACCTCAATACAGCTCATTCTGGAAGAAAATCTATTATGAATATGTG GTCGTTGACAAATCAATCTTGGGTGTTTCTATTCTGGATTCATTTATGTACAACCAGGAC TTGAAGCCCGTCGAAAAAGAAAGGCGGGTTTGGTCCTGGTACAATTATTGTTACTTCTGG CTTGCTGAATGTTTCAATATCAATACTTGGCAAATTGCAGCTACAGGTCTACAACTGGGT CTAAATTGGTGGCAGTGTTGGATAACAATTTGGATTGGGTACGGTTTCGTTGGTGCTTTT GTTGTTTTGGCCTCTAGAGTTGGATCTGCTTATCATTTGTCATTCCCTATATCATCTAGA GCATCATTCGGTATTTTCTTCTCTTTATGGCCCGTTATTAATAGAGTCGTCATGGCCATC GTTTGGTATAGTGTCCAAGCTTATATTGCGGCAACCCCCGTATCATTAATCCTGAAATCT ATCTTTGGAAAAGATTTACAAGACAGAATCCCAGATCACTTTGGATCACCGAATGCTACT ACTTACGAGTTCATGTGTTTTTTTATCTTTTGGGCTGCCAGTCTTCCATTTTTACTGGTC CCACCTCACAAAATTAGACACCTGTTTACTGTTAAAGCCGTCTTGGTTCCGTTTGCTTCT TTTGGTTTCTTAATTTGGGCTATCAGAAGAGCTCACGGGCGTATTGCCTTAGGATCTTTA ACCGATGTACAACCTCATGGCTCTGCCTTTTCGTGGGCTTTTCTAAGATCACTAATGCGT TGTATGGCTAATTTCTCCACAATGGTAATCAACGCTCCAGATTTCTCTAGATTTTCAAAA AACCCTAACTCCGCTTTATGGTCCCAATTAGTGTGCATTCCATTTTTGTTTTCCATCACT TGTTTAATTGGAATTCTAGTCACCGCAGCTGGTTATGAAATATACGGTATTAATTACTGG TCGCCACTCGATGTGCTAGAAAAATTTTTACAGACTACTTATAATAAGGGCACAAGAGCT GGTGTTTTCTTAATCTCTTTTGTTTTCGCCGTAGCTCAGTTAGGTACTAATATTTCTGCA AACTCATTATCGTGTGGAACTGATATGTCCGCTATCTTCCCCAAGTTTATCAATATCAAG CGTGGTTCATTATTTTGTGCAGCCATGGCGCTGTGTATTTGTCCATGGAATTTAATGGCA ACATCAAGTAAATTTACAATGGCTTTGTCCGCATATGCTATCTTTTTGTCCAGTATTGCC GGTGTTGTCTGCTCAGATTACTTTGTTGTTAGAAGAGGATATATCAAGCTAACACACATA TATTCCCATCAAAAGGGCTCTTTTTATATGTACGGAAACAGGTTTGGTATCAATTGGAGA GCTTTGGCTGCATATCTATGTGGGGTGGCTCCTTGCTTGCCCGGTTTCATCGCGGAGGTG GGCGCTCCCGCTATAAAGGTTTCTGATGGTGCTATGAAACTATATTACCTAAGTTACTGG GTAGGATATGGCTTGAGTTTTTCTTCTTATACTGCTCTGTGTTACTTCTTCCCTGTACCT GGGTGCCCTGTTAACAACATTATAAAGGACAAGGGCTGGTTCCAAAGATGGGCCAATGTC GATGATTTTGAAGAAGAGTGGAAAGACACAATTGAGAGGGATGACCTGGTAGATGACAAT ATTAGTGTCTACGAACACGAACACGAAAAGACTTTCATTTAA
Protein Properties
Pfam Domain Function
Protein Residues633
Protein Molecular Weight71735.10156
Protein Theoretical pI8.0
Signalling Regions
  • None
Transmembrane Regions
  • 143-163
  • 173-193
  • 197-217
  • 242-262
  • 268-288
  • 310-330
  • 350-370
  • 400-420
  • 442-462
  • 465-485
  • 521-541
  • 559-579
Protein Sequence>Uracil permease MPDNLSLHLSGSSKRLNSRQLMESSNETFAPNNVDLEKEYKSSQSNITTEVYEASSFEEK VSSEKPQYSSFWKKIYYEYVVVDKSILGVSILDSFMYNQDLKPVEKERRVWSWYNYCYFW LAECFNINTWQIAATGLQLGLNWWQCWITIWIGYGFVGAFVVLASRVGSAYHLSFPISSR ASFGIFFSLWPVINRVVMAIVWYSVQAYIAATPVSLMLKSIFGKDLQDKIPDHFGSPNAT TYEFMCFFIFWAASLPFLLVPPHKIRHLFTVKAVLVPFASFGFLIWAIRRAHGRIALGSL TDVQPHGSAFSWAFLRSLMGCMANFSTMVINAPDFSRFSKNPNSALWSQLVCIPFLFSIT CLIGILVTAAGYEIYGINYWSPLDVLEKFLQTTYNKGTRAGVFLISFVFAVAQLGTNISA NSLSCGTDMSAIFPKFINIKRGSLFCAAMALCICPWNLMATSSKFTMALSAYAIFLSSIA GVVCSDYFVVRRGYIKLTHIYSHQKGSFYMYGNRFGINWRALAAYLCGVAPCLPGFIAEV GAPAIKVSDGAMKLYYLSYWVGYGLSFSSYTALCYFFPVPGCPVNNIIKDKGWFQRWANV DDFEEEWKDTIERDDLVDDNISVYEHEHEKTFI
References
External Links
ResourceLink
Saccharomyces Genome Database FUR4
Uniprot IDP05316
Uniprot NameFUR4_YEAST
GenBank Gene IDX06830
Genebank Protein ID3706
General Reference
  • Jund, R., Weber, E., Chevallier, M. R. (1988). "Primary structure of the uracil transport protein of Saccharomyces cerevisiae." Eur J Biochem 171:417-424.3276521
  • Smits, P. H., De Haan, M., Maat, C., Grivell, L. A. (1994). "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene." Yeast 10 Suppl A:S75-S80.8091864
  • Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., Schaaff-Gerstenschlager, I., Scherens, B., Schwarzlose, C., Skala, J., Slonimski, P. P., Smits, P. H., Souciet, J. L., Steensma, H. Y., Stucka, R., Urrestarazu, A., van der Aart, Q. J., van Dyck, L., Vassarotti, A., Vetter, I., Vierendeels, F., Vissers, S., Wagner, G., de Wergifosse, P., Wolfe, K. H., Zagulski, M., Zimmermann, F. K., Mewes, H. W., Kleine, K. (1994). "Complete DNA sequence of yeast chromosome II." EMBO J 13:5795-5809.7813418
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956