Superoxide dismutase [Mn], mitochondrial (P00447)

Identification
NameSuperoxide dismutase [Mn], mitochondrial
SynonymsNot Available
Gene NameSOD2
Enzyme Class
Biological Properties
General FunctionInvolved in superoxide dismutase activity
Specific FunctionDestroys radicals which are normally produced within the cells and which are toxic to biological systems
Cellular LocationMitochondrion matrix
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00372SuperoxideShow
YMDB00862hydronShow
YMDB00888Hydrogen peroxideShow
YMDB00900oxygenShow
GO Classification
Component
Not Available
Function
binding
ion binding
cation binding
metal ion binding
antioxidant activity
superoxide dismutase activity
Process
oxidation reduction
oxygen and reactive oxygen species metabolic process
superoxide metabolic process
metabolic process
cellular metabolic process
Gene Properties
Chromosome Locationchromosome 8
LocusYHR008C
Gene Sequence>702 bp ATGTTCGCGAAAACAGCAGCTGCTAATTTAACCAAGAAGGGTGGTTTGTCATTGCTCTCC ACCACAGCAAGGAGAACCAAAGTCACCTTGCCAGACTTGAAGTGGGACTTCGGTGCATTG GAACCTTATATCTCCGGTCAAATCAACGAATTGCATTACACCAAGCACCATCAAACTTAT GTGAACGGATTCAACACTGCTGTTGACCAATTCCAAGAACTCTCAGATCTTCTGGCCAAG GAGCCCTCTCCCGCAAACGCAAGAAAAATGATTGCTATCCAACAAAACATCAAGTTCCAT GGCGGTGGTTTCACAAACCACTGTCTATTCTGGGAAAACCTGGCTCCAGAGTCGCAGGGC GGTGGTGAACCACCCACCGGCGCTTTGGCAAAGGCAATCGACGAGCAGTTTGGCAGTCTG GACGAGCTGATTAAGTTGACCAACACAAAGCTAGCAGGCGTGCAGGGCTCCGGATGGGCC TTCATTGTGAAAAACCTCTCTAATGGAGGCAAGCTGGACGTTGTTCAAACCTACAACCAG GATACCGTCACAGGCCCACTAGTTCCTCTAGTTGCCATTGACGCCTGGGAACACGCCTAC TACTTGCAGTACCAAAACAAGAAAGCCGACTACTTCAAAGCCATTTGGAATGTGGTCAAC TGGAAAGAAGCATCCAGAAGATTCGATGCTGGCAAGATCTGA
Protein Properties
Pfam Domain Function
Protein Residues233
Protein Molecular Weight25774.09961
Protein Theoretical pI8.87
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Superoxide dismutase [Mn], mitochondrial MFAKTAAANLTKKGGLSLLSTTARRTKVTLPDLKWDFGALEPYISGQINELHYTKHHQTY VNGFNTAVDQFQELSDLLAKEPSPANARKMIAIQQNIKFHGGGFTNHCLFWENLAPESQG GGEPPTGALAKAIDEQFGSLDELIKLTNTKLAGVQGSGWAFIVKNLSNGGKLDVVQTYNQ DTVTGPLVPLVAIDAWEHAYYLQYQNKKADYFKAIWNVVNWKEASRRFDAGKI
References
External Links
ResourceLink
Saccharomyces Genome Database SOD2
Uniprot IDP00447
Uniprot NameSODM_YEAST
GenBank Gene IDAY557821
Genebank Protein ID45269533
General Reference
  • Marres, C. A., Van Loon, A. P., Oudshoorn, P., Van Steeg, H., Grivell, L. A., Slater, E. C. (1985). "Nucleotide sequence analysis of the nuclear gene coding for manganese superoxide dismutase of yeast mitochondria, a gene previously assumed to code for the Rieske iron-sulphur protein." Eur J Biochem 147:153-161.3882422
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Schrank, I. S., Sims, P. F., Oliver, S. G. (1988). "Functional expression of the yeast Mn-superoxide dismutase gene in Escherichia coli requires deletion of the signal peptide sequence." Gene 73:121-130.3072251
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666