Proline Metabolism

Source	ID	Pathway
PathWhiz	PW002365

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight	Structure
YMDB00088	Ubiquinone Q1 727-81-1	2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en-1-yl)cyclohexa-2,5-diene-1,4-dione	C₁₄H₁₈O₄ 250.2903
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00110	NAD 53-84-9	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00143	NADH 58-68-4	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid	C₂₁H₂₉N₇O₁₄P₂ 665.441
YMDB00233	L-Glutamic acid 5-phosphate 13254-53-0	(2S)-2-amino-5-oxo-5-(phosphonooxy)pentanoic acid	C₅H₁₀NO₇P 227.1092
YMDB00243	1-Pyrroline-5-carboxylic acid 2906-39-0	3,4-dihydro-2H-pyrrole-2-carboxylic acid	C₅H₇NO₂ 113.1146
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00378	L-Proline 147-85-3	(2S)-pyrrolidine-2-carboxylic acid	C₅H₉NO₂ 115.1305
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00907	phosphate 14265-44-2	phosphoric acid	O₄P 94.9714
YMDB00914	ADP 58-64-0	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₁₀H₁₅N₅O₁₀P₂ 427.2011
YMDB00918	l-Glutamic-gamma-semialdehyde 496-92-4	(2S)-2-amino-5-oxopentanoic acid	C₅H₉NO₃ 131.1299
YMDB16248	QH(2)	2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en-1-yl)benzene-1,4-diol	C₁₄H₂₀O₄ 252.3062
YMDB16257	γ-L-glutamyl 5-phosphate	(2S)-2-amino-5-(hydrogen phosphonatooxy)-5-oxopentanoate	C₅H₈NO₇P 225.094

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P32264	PRO1 YDR300C	Glutamate 5-kinase	Enzyme	Adenosine triphosphate L-Glutamic acid 5-phosphate L-Glutamic acid ADP γ-L-glutamyl 5-phosphate
P32263	PRO3 YER023W	Pyrroline-5-carboxylate reductase	Enzyme	NAD NADH 1-Pyrroline-5-carboxylic acid L-Proline NAD(+) 1-Pyrroline-5-carboxylate NADPH NADP 1-pyrroline-3-hydroxy-5-carboxylic acid trans-4-hydroxy-L-proline hydron
P54885	PRO2 YOR323C	Gamma-glutamyl phosphate reductase	Enzyme	NAD NADH L-Glutamic acid 5-phosphate NAD(+) NADPH NADP hydron phosphate l-Glutamic-gamma-semialdehyde
P32872		Aldehyde dehydrogenase 2, mitochondrial		Ubiquinone Q1 NAD NADH 1-Pyrroline-5-carboxylic acid L-Glutamic acid L-Proline hydron water l-Glutamic-gamma-semialdehyde QH(2)