1-MLCL(0:0/10:0/18:0/18:0) (YMDB11553)

Identification
YMDB IDYMDB11553
Name1-MLCL(0:0/10:0/18:0/18:0)
SpeciesSaccharomyces cerevisiae
StrainBrewer's yeast
Description1-MLCL(0:0/10:0/18:0/18:0) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails, instead of the usual two. 1-MLCL(0:0/10:0/18:0/18:0) contains one chain of at the C1 position, one chain of decanoic acid at the C2 position, two chains of octadecanoic acid at the C3 and C4 positions. MLCL is present in eukaryotes as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from a cardiolipin results in generation of monolysocardiolipin (MLCL). MLCL has been used as an inter­mediate in the synthesis of spin-labeled CL to study the interaction of CL with mitochondrial enzymes. Because a role for MLCL has been suggested in apoptosis, this molecule has been used to study its interaction with various enzymes involved in lipid remodeling and apoptosis. There are two species of monolysocardiolipins, 1-MLCL which is missing a fatty acid in position R1 the and 2-MLCL which is missing a fatty acid in position R4.
Structure
Thumb
MOLSDFPDBSMILESInChI
SynonymsNot Available
CAS numberNot Available
WeightAverage: 1087.401
Monoisotopic: 1086.711261394
InChI KeyFVCXLPIVGYZHKS-IHSNFILASA-N
InChIInChI=1S/C55H108O16P2/c1-4-7-10-13-16-18-20-22-24-26-28-30-33-35-38-41-53(58)65-47-52(71-55(60)43-40-37-34-31-29-27-25-23-21-19-17-14-11-8-5-2)49-69-73(63,64)67-46-50(57)45-66-72(61,62)68-48-51(44-56)70-54(59)42-39-36-32-15-12-9-6-3/h50-52,56-57H,4-49H2,1-3H3,(H,61,62)(H,63,64)/t50-,51+,52+/m0/s1
IUPAC Name[(2R)-2,3-bis(octadecanoyloxy)propoxy][(2S)-3-({[(2R)-2-(decanoyloxy)-3-hydroxypropoxy](hydroxy)phosphoryl}oxy)-2-hydroxypropoxy]phosphinic acid
Traditional IUPAC Name(2R)-2,3-bis(octadecanoyloxy)propoxy((2S)-3-{[(2R)-2-(decanoyloxy)-3-hydroxypropoxy(hydroxy)phosphoryl]oxy}-2-hydroxypropoxy)phosphinic acid
Chemical FormulaC55H108O16P2
SMILES[H][C@](O)(COP(O)(=O)OC[C@@]([H])(CO)OC(=O)CCCCCCCCC)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC
Chemical Taxonomy
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.00033 g/LALOGPS
logP7.94ALOGPS
logP15.9ChemAxon
logS-6.5ALOGPS
pKa (Strongest Acidic)1.59ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area230.88 ŲChemAxon
Rotatable Bond Count60ChemAxon
Refractivity287.31 m³·mol⁻¹ChemAxon
Polarizability128.11 ųChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • Mitochondrion membrane
Organoleptic PropertiesNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(10:0/18:0/18:0/26:0)PW005627 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/18:0/18:0/26:1(11Z))PW005628 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/18:0/18:0/26:1(9Z))PW005629 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB Reactions
CL(10:0/18:0/18:0/18:1(11Z)) → 1-MLCL(0:0/10:0/18:0/18:0)
CL(10:0/18:0/18:0/18:1(9Z)) → 1-MLCL(0:0/10:0/18:0/18:0)
CL(10:0/18:0/18:0/20:1(11Z)) → 1-MLCL(0:0/10:0/18:0/18:0)
CL(10:0/18:0/18:0/20:1(13Z)) → 1-MLCL(0:0/10:0/18:0/18:0)
CL(10:0/18:0/18:0/22:0) → 1-MLCL(0:0/10:0/18:0/18:0)
KEGG ReactionsNot Available
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-9443104272-5af848095ae7c0a88b7cJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-066r-7695305282-63624dea2300333d5447JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-056r-9588204510-66fbfac09d7607ed5685JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0159-4391101042-a49a5b94ddba730348efJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0059-9272200120-3665e452010f422d200fJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9141000000-4bcb2a27614008861abbJSpectraViewer
References
References:
  • Baile MG, Lu YW, Claypool SM. (2014). "The topology and regulation of cardiolipin biosynthesis and remodeling in yeast." Chem Phys Lipids. 2014 Apr;179:25-31. doi: 10.1016/j.chemphyslip.2013.10.008. Epub 2013 Nov 1.24184646
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI IDNot Available
HMDB IDNot Available
Pubchem Compound IDNot Available
Kegg IDNot Available
ChemSpider IDNot Available
FOODB IDNot Available
Wikipedia IDNot Available
BioCyc IDNot Available