{"ymdb_id":"YMDB00687","created_at":"2011-05-29T18:43:30.000Z","updated_at":"2016-09-08T18:35:46.000Z","name":"D-fructose 1,6-bisphosphate","cas":"488-69-7","state":"Solid","melting_point":null,"description":"Fructose 1,6-bisphosphate (also known as Harden-young ester) is fructose sugar phosphorylated on carbons 1 and 6 (i.e., is a fructosephosphate). The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-biphosphate at some point. [Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"16905","hmdb_id":"HMDB01058","kegg_id":"C00354","pubchem_id":"718","cs_id":"76632","foodb_id":null,"wikipedia_link":"Fructose_1,6-bisphosphate","biocyc_id":"FRUCTOSE-16-DIPHOSPHATE","iupac":"{[(3S,4R,5R)-3,4,5-trihydroxy-2-oxo-6-(phosphonooxy)hexyl]oxy}phosphonic acid","traditional_iupac":"D-fructose 1,6-bisphosphate","logp":"-3.514163954666666","pka":"1.6633055259475853","alogps_solubility":"1.36e+01 g/l","alogps_logp":"-1.61","alogps_logs":"-1.40","acceptor_count":"10","donor_count":"7","rotatable_bond_count":"9","polar_surface_area":"211.27999999999997","refractivity":"59.3076","polarizability":"25.525007836038164","formal_charge":"0","physiological_charge":"-4","pka_strongest_basic":"-3.5447528314482835","pka_strongest_acidic":"1.006253866577405","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[".alpha.-D-Fructofuranose 1,6-diphosphate",".alpha.-D-Fructofuranose, 1,6-bis(dihydrogen phosphate)","1,6-di-O-phosphono-D-fructose","beta-d-fructofuranose-1,6-diphosphate","D-Fructose 1,6-biphosphate","D-Fructose 1,6-bis(dihydrogen phosphate)","D-Fructose 1,6-bisphosphate","D-Fructose 1,6-diphosphate","D-fructose-1,6-bisphosphate","D-fructose-1,6-diphosphate","Diphosphofructose","Esafosfan","Esafosfina","fbp, fructose diphosphate","FDP","Fosfructose","Fructose 1,6-bis","Fructose 1,6-bisphosphate","Fructose 1,6-diphosphate","Fructose 1,6-diphosphic acid","fructose-1,6-bisphosphate","FRUCTOSE,L,6-DIPHOSPHASE","Harden-Young ester"],"pathways":[{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Glycolysis I","kegg_map_id":null},{"name":"Ethanol fermentation","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":168195,"citation":"Schray, K. J., Fishbein, R., Bullard, W. P., Benkovic, S. J. (1975). \"The anomeric form of D-fructose 1,6-bisphosphate used as substrate in the muscle and yeast aldolase reactions.\" J Biol Chem 250:4883-4887."},{"pubmed_id":770188,"citation":"Wurster, B., Hess, B. (1976). \"Tautomeric and anomeric specificity of allosteric activation of yeast pyruvate kinase by D-fructose 1, 6-bisphosphate and its relevance in D-glucose catabolism.\" FEBS Lett 63:17-21."},{"pubmed_id":12722184,"citation":"Barnett, J. A. (2003). \"A history of research on yeasts 5: the fermentation pathway.\" Yeast 20:509-543."},{"pubmed_id":3007939,"citation":"Heinisch, J. (1986). \"Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast.\" Mol Gen Genet 202:75-82."},{"pubmed_id":8435847,"citation":"Boles, E., Zimmermann, F. K. (1993). \"Saccharomyces cerevisiae phosphoglucose isomerase and fructose bisphosphate aldolase can be replaced functionally by the corresponding enzymes of Escherichia coli and Drosophila melanogaster.\" Curr Genet 23:187-191."}],"proteins":[{"created_at":"2011-05-26T17:44:52.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"6-phosphofructokinase subunit alpha","uniprot_id":"P16861","uniprot_name":"K6PF1_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK1","num_residues":987,"molecular_weight":"107969.0","theoretical_pi":"6.35","general_function":"Involved in 6-phosphofructokinase activity","specific_function":"ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate","reactions":[{"id":2481,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3807,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006321","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M26943","genbank_protein_id":"172138","gene_card_id":"PFK1","chromosome_location":"chromosome 7","locus":"YGR240C","synonyms":["6PF-1-K subunit alpha","Phosphofructokinase 1","Phosphohexokinase"],"enzyme_classes":["2.7.1.11"],"go_classes":[{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" cell part"},{"category":"Component","description":" 6-phosphofructokinase complex"},{"category":"Component","description":" intracellular part"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PFK","identifier":"PF00365"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Glycolysis I","kegg_map_id":null}],"gene_sequence":"ATGCAATCTCAAGATTCATGCTACGGTGTTGCATTCAGATCTATCATCACAAATGATGAAGCTTTATTCAAGAAGACCATTCACTTTTATCACACTCTAGGATTTGCAACTGTGAAAGATTTCAACAAATTCAAACATGGTGAAAATAGCTTACTATCTTCAGGGACTTCCCAAGATTCCTTGAGAGAAGTTTGGTTAGAATCTTTCAAGTTGAGTGAGGTTGATGCTTCTGGGTTCCGTATACCACAACAAGAAGCTACTAACAAGGCTCAAAGTCAAGGTGCTCTATTAAAGATTCGTTTAGTGATGTCTGCTCCAATCGATGAAACTTTCGACACCAACGAAACCGCCACAATCACTTATTTCTCTACTGATTTGAACAAGATTGTCGAGAAATTCCCAAAACAAGCCGAAAAATTGTCCGATACCTTAGTGTTTTTGAAAGATCCAATGGGCAACAACATCACCTTCTCAGGCTTAGCTAATGCAACCGATTCCGCTCCAACTTCCAAAGATGCTTTCTTAGAAGCTACCTCCGAAGACGAAATCATCTCTAGAGCTTCTTCCGATGCTTCTGACTTACTAAGACAAACATTGGGCTCTTCTCAAAAGAAGAAGAAGATTGCTGTCATGACTTCTGGTGGTGATTCTCCAGGTATGAATGCCGCTGTTCGTGCCGTTGTTCGTACAGGTATACATTTCGGCTGTGATGTTTTTGCTGTTTACGAAGGTTACGAAGGTTTACTAAGAGGCGGTAAATATTTAAAGAAAATGGCTTGGGAAGATGTCAGAGGTTGGTTAAGTGAAGGTGGTACTTTGATTGGTACTGCTCGTTCTATGGAATTCAGAAAGCGTGAGGGTCGTAGACAAGCTGCAGGCAATTTAATTTCGCAAGGTATTGACGCTTTGGTTGTTTGTGGTGGTGATGGTTCTTTAACCGGTGCTGATCTTTTCAGACACGAATGGCCATCTTTGGTTGATGAATTGGTTGCAGAAGGTAGATTCACTAAAGAAGAAGTCGCCCCATACAAGAATTTGTCCATTGTTGGTCTTGTCGGTTCCATCGATAATGATATGTCTGGTACTGACTCTACCATTGGTGCTTATTCTGCTTTGGAAAGAATCTGTGAAATGGTTGACTACATTGATGCCACCGCTAAATCCCACTCCCGTGCCTTTGTTGTTGAAGTTATGGGTAGACATTGTGGTTGGTTGGCCTTGATGGCTGGTATTGCTACCGGTGCCGATTACATTTTTATTCCAGAAAGAGCTGTTCCTCACGGAAAATGGCAGGACGAATTGAAGGAAGTGTGCCAAAGACACAGAAGTAAGGGTAGAAGAAATAACACAATTATTGTCGCTGAAGGTGCTTTAGATGATCAATTAAACCCTGTTACTGCCAATGACGTCAAAGATGCTTTGATTGAATTGGGTCTAGACACCAAGGTAACCATTCTAGGTCACGTTCAAAGAGGTGGTACAGCTGTTGCTCATGACAGATGGTTAGCTACTCTACAAGGTGTCGATGCTGTTAAGGCCGTTCTGGAATTTACCCCTGAAACTCCTTCTCCATTAATTGGTATTTTAGAAAACAAGATAATTAGAATGCCATTGGTTGAATCTGTGAAGTTGACTAAATCTGTTGCCACTGCCATTGAAAACAAAGATTTCGATAAGGCAATTTCTTTAAGAGACACAGAATTTATTGAACTTTACGAAAACTTCTTATCCACTACCGTTAAAGATGATGGTTCCGAATTATTGCCAGTATCTGACAGACTAAACATTGGTATTGTCCATGTTGGTGCCCCATCTGCTGCTTTGAACGCTGCCACCCGTGCCGCAACTCTATACTGTTTGTCTCACGGCCATAAACCATACGCTATCATGAATGGTTTCAGTGGATTGATTCAAACCGGTGAAGTGAAGGAACTATCATGGATTGATGTCGAAAACTGGCATAACTTGGGTGGTTCCGAAATCGGTACGAACAGATCTGTTGCTTCAGAAGATTTGGGTACCATTGCTTACTACTTCCAAAAGAACAAGCTAGACGGTTTGATTATTCTTGGTGGTTTTGAAGGTTTCAGGTCCTTGAAGCAATTGCGTGACGGTAGAACCCAACACCCAATCTTTAACATTCCAATGTGTTTGATTCCAGCCACTGTTTCTAATAACGTTCCAGGTACTGAATACTCACTTGGTGTTGATACCTGTTTGAACGCATTAGTCAATTACACTGATGACATCAAACAAAGTGCTTCTGCCACAAGAAGAAGAGTCTTCGTCTGTGAAGTCCAAGGTGGTCACTCTGGTTACATCGCTTCTTTCACCGGTTTAATCACTGGTGCTGTTTCCGTGTACACTCCAGAAAAGAAGATCGACTTAGCTTCTATCAGAGAAGATATAACTCTATTAAAAGAGAACTTCCGTCACGACAAAGGTGAAAACAGAAACGGTAAGCTATTGGTTAGAAACGAACAAGCTTCTAGCGTATATAGCACTCAATTGTTGGCTGACATCATCTCTGAAGCAAGCAAGGGTAAGTTTGGTGTTAGAACTGCTATCCCAGGCCATGTTCAACAAGGTGGTGTTCCATCTTCTAAAGACCGTGTCACCGCTTCCAGATTTGCTGTCAAATGTATCAAGTTTATCGAACAATGGAACAAGAAAAATGAAGCTTCTCCAAACACTGACGCTAAGGTTTTGAGATTCAAGTTCGATACTCACGGTGAAAAGGTACCAACTGTTGAGCACGAAGATGACTCTGCTGCTGTTATCTGTGTTAATGGTTCTCACGTTTCCTTCAAGCCAATTGCTAACCTTTGGGAAAACGAAACCAACGTTGAATTAAGAAAGGGTTTTGAAGTTCACTGGGCTGAATACAACAAGATTGGTGACATCCTGTCCGGTAGATTAAAGTTGAGAGCTGAGGTAGCCGCTTTAGCCGCTGAAAACAAATGA","protein_sequence":"MQSQDSCYGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLSSGTSQDSLREVWLESFKLSEVDASGFRIPQQEATNKAQSQGALLKIRLVMSAPIDETFDTNETATITYFSTDLNKIVEKFPKQAEKLSDTLVFLKDPMGNNITFSGLANATDSAPTSKDAFLEATSEDEIISRASSDASDLLRQTLGSSQKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFKFDTHGEKVPTVEHEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVAALAAENK"},{"created_at":"2011-05-26T17:45:36.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"6-phosphofructokinase subunit beta","uniprot_id":"P16862","uniprot_name":"K6PF2_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK2","num_residues":959,"molecular_weight":"104617.0","theoretical_pi":"6.65","general_function":"Involved in 6-phosphofructokinase activity","specific_function":"ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate","reactions":[{"id":2481,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M26944","genbank_protein_id":"172140","gene_card_id":"PFK2","chromosome_location":"chromosome 13","locus":"YMR205C","synonyms":["6PF-1-K subunit beta","Phosphofructokinase 2","Phosphohexokinase"],"enzyme_classes":["2.7.1.11"],"go_classes":[{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" cell part"},{"category":"Component","description":" 6-phosphofructokinase complex"},{"category":"Component","description":" intracellular part"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PFK","identifier":"PF00365"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Ethanol fermentation","kegg_map_id":null}],"gene_sequence":"ATGACTGTTACTACTCCTTTTGTGAATGGTACTTCTTATTGTACCGTCACTGCATATTCCGTTCAATCTTATAAAGCTGCCATAGATTTTTACACCAAGTTTTTGTCATTAGAAAACCGCTCTTCTCCAGATGAAAACTCCACTTTATTGTCTAACGATTCCATCTCTTTGAAGATCCTTCTACGTCCTGATGAAAAAATCAATAAAAATGTTGAGGCTCATTTGAAGGAATTGAACAGTATTACCAAGACTCAAGACTGGAGATCACATGCCACCCAATCCTTGGTATTTAACACTTCCGACATCTTGGCAGTCAAGGACACTCTAAATGCTATGAACGCTCCTCTTCAAGGCTACCCAACAGAACTATTTCCAATGCAGTTGTACACTTTGGACCCATTAGGTAACGGTGTTGGTGTTACTTCTACTAAGAACGCAGTTTCAACCAAGCCAACTCCACCACCAGCACCAGAAGCTTCTGCTGAGTCTGGTCTTTCCTCTAAAGTTCACTCTTACACTGATTTGGCTTACCGTATGAAAACCACCGACACCTATCCATCTCTGCCAAAGCCATTGAACAGGCCTCAAAAGGCAATTGCCGTCATGACTTCCGGTGGTGATGCTCCAGGTATGAACTCTAACGTTAGAGCCATCGTGCGTTCCGCTATCTTCAAAGGTTGTCGTGCCTTTGTTGTCATGGAAGGTTATGAAGGTTTGGTTCGTGGTGGTCCAGAATACATCAAGGAATTCCACTGGGAAGACGTCCGTGGTTGGTCTGCTGAAGGTGGTACCAACATTGGTACTGCCCGTTGTATGGAATTCAAGAAGCGCGAAGGTAGATTATTGGGTGCCCAACATTTGATTGAGGCCGGTGTCGATGCTTTGATCGTTTGTGGTGGTGACGGTTCTTTGACTGGTGCTGATCTGTTTAGATCAGAATGGCCTTCTTTGATCGAGGAATTGTTGAAAACAAACAGAATTTCCAACGAACAATACGAAAGAATGAAGCATTTGAATATTTGCGGTACTGTCGGTTCTATTGATAACGATATGTCCACCACGGATGCTACTATTGGTGCTTACTCTGCCTTGGACAGAATCTGTAAGGCCATCGATTACGTTGAAGCCACTGCCAACTCTCACTCAAGAGCTTTCGTTGTTGAAGTTATGGGTAGAAACTGTGGTTGGTTAGCTTTATTAGCTGGTATCGCCACTTCCGCTGACTATATCTTTATTCCAGAGAAGCCAGCCACTTCCAGCGAATGGCAAGATCAAATGTGTGACATTGTCTCCAAGCACAGATCAAGGGGTAAGAGAACCACCATTGTTGTTGTTGCAGAAGGTGCTATCGCTGCTGACTTGACCCCAATTTCTCCAAGCGACGTCCACAAAGTTCTAGTTGACAGATTAGGTTTGGATACAAGAATTACTACCTTAGGTCACGTTCAAAGAGGTGGTACTGCTGTTGCTTACGACCGTATCTTGGCTACTTTACAAGGTCTTGAGGCCGTTAATGCCGTTTTGGAATCCACTCCAGACACCCCATCACCATTGATTGCTGTTAACGAAAACAAAATTGTTCGTAAACCATTAATGGAATCCGTCAAGTTGACCAAAGCAGTTGCAGAAGCCATTCAAGCTAAGGATTTCAAGAGAGCTATGTCTTTAAGAGACACTGAGTTCATTGAACATTTAAACAATTTCATGGCTATCAACTCTGCTGACCACAACGAACCAAAGCTACCAAAGGACAAGAGACTGAAGATTGCCATTGTTAATGTCGGTGCTCCAGCTGGTGGTATCAACTCTGCCGTCTACTCGATGGCTACTTACTGTATGTCCCAAGGTCACAGACCATACGCTATCTACAATGGTTGGTCTGGTTTGGCAAGACATGAAAGTGTTCGTTCTTTGAACTGGAAGGATATGTTGGGTTGGCAATCCCGTGGTGGTTCTGAAATCGGTACTAACAGAGTCACTCCAGAAGAAGCAGATCTAGGTATGATTGCTTACTATTTCCAAAAGTACGAATTTGATGGTTTGATCATCGTTGGTGGTTTCGAAGCTTTTGAATCTTTACATCAATTAGAGAGAGCAAGAGAAAGTTATCCAGCTTTCAGAATCCCAATGGTCTTGATACCAGCTACTTTGTCTAACAATGTTCCAGGTACTGAATACTCTTTGGGTTCTGATACCGCTTTGAATGCTCTAATGGAATACTGTGATGTTGTTAAACAATCCGCTTCTTCAACCAGAGGTAGAGCCTTCGTTGTCGATTGTCAAGGTGGTAACTCAGGCTATTTGGCCACTTACGCTTCTTTGGCTGTTGGTGCTCAAGTCTCTTATGTCCCAGAAGAAGGTATTTCTTTGGAGCAATTGTCCGAGGATATTGAATACTTAGCTCAATCTTTTGAAAAGGCAGAAGGTAGAGGTAGATTTGGTAAATTGATTTTGAAGAGTACAAACGCTTCTAAGGCTTTATCAGCCACTAAATTGGCTGAAGTTATTACTGCTGAAGCCGATGGCAGATTTGACGCTAAGCCAGCTTATCCAGGTCATGTACAACAAGGTGGTTTGCCATCTCCAATTGATAGAACAAGAGCCACTAGAATGGCCATTAAAGCTGTCGGCTTCATCGAAGACAACCAAGCTGCCATTGCTGAAGCTCGTGCTGCCGAAGAAAACTTCAACGCTGATGACAAGACCATTTCTGACACTGCTGCTGTCGTTGGTGTTAAGGGTTCACATGTCGTTTACAACTCCATTAGACAATTGTATGACTATGAAACTGAAGTTTCCATGAGAATGCCAAAGGTCATTCACTGGCAAGCTACCAGACTCATTGCTGACCATTTGGTTGGAAGAAAGAGAGTTGATTAA","protein_sequence":"MTVTTPFVNGTSYCTVTAYSVQSYKAAIDFYTKFLSLENRSSPDENSTLLSNDSISLKILLRPDEKINKNVEAHLKELNSITKTQDWRSHATQSLVFNTSDILAVKDTLNAMNAPLQGYPTELFPMQLYTLDPLGNVVGVTSTKNAVSTKPTPPPAPEASAESGLSSKVHSYTDLAYRMKTTDTYPSLPKPLNRPQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKRVD"},{"created_at":"2011-05-26T17:47:10.000Z","updated_at":"2011-05-29T05:06:20.000Z","name":"Fructose-1,6-bisphosphatase","uniprot_id":"P09201","uniprot_name":"F16P_YEAST","enzyme":true,"transporter":false,"gene_name":"FBP1","num_residues":348,"molecular_weight":"38262.19922","theoretical_pi":"5.87","general_function":"Involved in phosphoric ester hydrolase activity","specific_function":"D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate","reactions":[{"id":1551,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2482,"direction":"\u003e","locations":"Cytoplasmic","altext":"D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY692816","genbank_protein_id":"51013083","gene_card_id":"FBP1","chromosome_location":"chromosome 12","locus":"YLR377C","synonyms":["FBPase","D-fructose-1,6-bisphosphate 1-phosphohydrolase"],"enzyme_classes":["3.1.3.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"FBPase","identifier":"PF00316"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGCCAACTCTAGTAAATGGACCAAGAAGAGACTCTACCGAAGGGTTTGATACCGATATCATCACTCTTCCTAGATTCATAATCGAGCACCAGAAGCAATTTAAGAACGCTACTGGTGATTTCACATTAGTACTGAATGCCTTGCAATTCGCGTTCAAATTTGTATCTCACACCATCAGACGTGCTGAATTGGTTAACTTGGTTGGGTTAGCAGGCGCTTCCAACTTCACTGGTGACCAGCAAAAGAAGTTGGACGTTCTAGGTGATGAAATATTTATCAATGCCATGAGGGCTAGTGGGATCATCAAGGTCCTTGTATCTGAAGAACAGGAAGACTTGATCGTTTTTCCCACAAACACGGGCTCATACGCAGTGTGTTGTGATCCTATTGATGGCTCCTCAAATTTGGACGCCGGTGTCTCCGTTGGAACTATCGCGTCTATATTCAGACTGCTACCAGACTCATCAGGTACTATAAACGACGTACTGAGATGTGGTAAAGAAATGGTAGCCGCTTGCTATGCCATGTACGGATCCTCTACGCATCTAGTATTGACATTGGGTGATGGAGTTGATGGGTTTACCTTAGACACAAACTTGGGCGAATTCATCTTGACTCATCCTAACTTAAGAATTCCGCCTCAAAAGGCCATCTACTCAATTAATGAAGGTAACACCCTCTACTGGAACGAGACTATAAGAACATTTATTGAGAAAGTCAAACAACCCCAAGCAGACAACAACAACAAGCCTTTCTCGGCTAGGTATGTTGGATCCATGGTTGCTGATGTTCACAGGACGTTTCTTTACGGTGGCCTTTTCGCATACCCTTGCGACAAGAAGAGCCCCAACGGAAAACTGAGGTTGCTTTATGAGGCCTTCCCAATGGCTTTCTTAATGGAACAAGCAGGGGGAAAAGCGGTCAACGATCGCGGAGAGAGAATCTTGGATTTGGTGCCAAGTCATATCCATGACAAATCTTCTATTTGGTTGGGTTCTTCAGGTGAAATTGACAAATTTTTAGACCATATTGGCAAGTCACAGTAG","protein_sequence":"MPTLVNGPRRDSTEGFDTDIITLPRFIIEHQKQFKNATGDFTLVLNALQFAFKFVSHTIRRAELVNLVGLAGASNFTGDQQKKLDVLGDEIFINAMRASGIIKVLVSEEQEDLIVFPTNTGSYAVCCDPIDGSSNLDAGVSVGTIASIFRLLPDSSGTINDVLRCGKEMVAACYAMYGSSTHLVLTLGDGVDGFTLDTNLGEFILTHPNLRIPPQKAIYSINEGNTLYWNETIRTFIEKVKQPQADNNNKPFSARYVGSMVADVHRTFLYGGLFAYPCDKKSPNGKLRLLYEAFPMAFLMEQAGGKAVNDRGERILDLVPSHIHDKSSIWLGSSGEIDKFLDHIGKSQ"},{"created_at":"2011-05-26T19:32:26.000Z","updated_at":"2011-07-22T17:54:34.000Z","name":"Fructose-bisphosphate aldolase","uniprot_id":"P14540","uniprot_name":"ALF_YEAST","enzyme":true,"transporter":false,"gene_name":"FBA1","num_residues":359,"molecular_weight":"39620.5","theoretical_pi":"5.59","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis","reactions":[{"id":1434,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1552,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1961,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2577,"direction":"\u003e","locations":null,"altext":"D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X15003","genbank_protein_id":"3696","gene_card_id":"FBA1","chromosome_location":"chromosome 11","locus":"YKL060C","synonyms":["FBP aldolase","FBPA","Fructose-1,6-bisphosphate aldolase"],"enzyme_classes":["4.1.2.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aldehyde-lyase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" fructose-bisphosphate aldolase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycolysis"}],"pfams":[{"name":"F_bP_aldolase","identifier":"PF01116"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGGGTGTTGAACAAATCTTAAAGAGAAAGACCGGTGTCATCGTTGGTGAAGATGTCCACAACTTATTCACTTACGCTAAGGAACACAAGTTCGCTATTCCAGCTATTAACGTCACCTCTTCTTCTACTGCCGTCGCTGCTTTAGAAGCTGCTAGAGACAGCAAGTCCCCAATCATTTTGCAAACCTCTAACGGTGGTGCTGCTTACTTCGCTGGTAAGGGTATCTCTAACGAAGGTCAAAATGCTTCCATCAAGGGTGCTATTGCCGCTGCCCACTACATCAGATCCATTGCTCCAGCTTACGGTATCCCAGTTGTCTTACACTCTGACCACTGTGCCAAGAAGTTGTTGCCATGGTTCGATGGTATGTTGGAAGCTGATGAAGCTTACTTCAAGGAACACGGTGAACCATTATTCTCCTCCCACATGTTGGATTTGTCTGAAGAAACCGATGAAGAAAACATCTCTACTTGTGTCAAGTACTTCAAGAGAATGGCCGCTATGGACCAATGGTTAGAAATGGAAATCGGTATTACCGGTGGTGAAGAAGATGGTGTTAACAACGAAAACGCTGACAAGGAAGACTTGTACACCAAGCCAGAACAAGTTTACAACGTCTACAAGGCTTTGCACCCAATCTCTCCAAACTTCTCCATTGCTGCTGCTTTCGGTAACTGTCACGGTTTGTACGCTGGTGACATCGCTTTGAGACCAGAAATCTTGGCTGAACACCAAAAGTACACCAGAGAACAAGTTGGTTGCAAGGAAGAAAAGCCATTGTTCTTGGTCTTCCACGGTGGTTCCGGTTCTACTGTCCAAGAATTCCACACTGGTATTGACAACGGTGTTGTCAAGGTCAACTTGGACACTGACTGTCAATACGCTTACTTGACTGGTATCAGAGACTACGTCTTGAACAAGAAGGACTACATAATGTCCCCAGTCGGTAACCCAGAAGGTCCAGAAAAGCCAAACAAGAAGTTCTTCGACCCAAGAGTCTGGGTTAGAGAAGGTGAAAAGACCATGGGTGCTAAGATCACCAAGTCTTTGGAAACTTTCCGTACCACTAACACTTTATAA","protein_sequence":"MGVEQILKRKTGVIVGEDVHNLFTYAKEHKFAIPAINVTSSSTAVAALEAARDSKSPIILQTSNGGAAYFAGKGISNEGQNASIKGAIAAAHYIRSIAPAYGIPVVLHSDHCAKKLLPWFDGMLEADEAYFKEHGEPLFSSHMLDLSEETDEENISTCVKYFKRMAAMDQWLEMEIGITGGEEDGVNNENADKEDLYTKPEQVYNVYKALHPISPNFSIAAAFGNCHGLYAGDIALRPEILAEHQKYTREQVGCKEEKPLFLVFHGGSGSTVQEFHTGIDNGVVKVNLDTDCQYAYLTGIRDYVLNKKDYIMSPVGNPEGPEKPNKKFFDPRVWVREGEKTMGAKITKSLETFRTTNTL"}]}