{"ymdb_id":"YMDB00152","created_at":"2011-05-29T16:01:55.000Z","updated_at":"2016-10-18T17:11:18.000Z","name":"L-Valine","cas":"72-18-4","state":"Solid","melting_point":"295-300 oC","description":"Valine (abbreviated as Val or V) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a nonpolar branched chain amino acid, because of the hydrophobic nature of its branched alkyl side chain. S. cerevisiae degrade the branched-chain amino acids (valine, leucine, and iso-leucine) via the Ehrlich pathway.  This pathway consists of 3 steps: 1) deamination of the amino acid to the corresponding alpha-keto acid; 2) decarboxylation of the resulting alpha-keto acid to the respective aldehyde; and, 3) reduction of the aldehyde to form the corresponding long chain or complex alcohol, known as a fusel alcohol or fusel oil. Fusel alcohols are important flavor and aroma compounds in yeast-fermented food products and beverages. Each of the three steps in branched-chain amino acid degradation can be catalyzed by more than one isozyme; which enzyme is used appears to depend on the amino acid, the carbon source and the stage of growth of the culture.","experimental_water_solubility":"58.5 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-2.26 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":"Kinoshita, Shukuo; Udaka, Shigezo.  L-Valine production by fermentation.    (1962),     2 pp.","chebi_id":"16414","hmdb_id":"HMDB00883","kegg_id":"C00183","pubchem_id":"1182","cs_id":"6050","foodb_id":null,"wikipedia_link":"Valine","biocyc_id":"VAL","iupac":"(2S)-2-amino-3-methylbutanoic acid","traditional_iupac":"L-valine","logp":"-1.953136464200883","pka":null,"alogps_solubility":"2.14e+02 g/l","alogps_logp":"-2.29","alogps_logs":"0.26","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"2","polar_surface_area":"63.31999999999999","refractivity":"29.4929","polarizability":"12.191412403732404","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.599176382928611","pka_strongest_acidic":"2.7172733818557755","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-Amino-3-methylbutanoate","(2S)-2-Amino-3-methylbutanoic acid","(S)-2-amino-3-methyl-Butanoate","(S)-2-amino-3-methyl-Butanoic acid","(S)-2-Amino-3-methylbutanoate","(S)-2-Amino-3-methylbutanoic acid","(S)-2-Amino-3-methylbutyrate","(S)-2-Amino-3-methylbutyric acid","(S)-a-Amino-b-methylbutyrate","(S)-a-Amino-b-methylbutyric acid","(S)-alpha-Amino-beta-methylbutyrate","(S)-alpha-Amino-beta-methylbutyric acid","(S)-Valine","2-Amino-3-methylbutanoate","2-Amino-3-methylbutanoic acid","2-Amino-3-methylbutyrate","2-Amino-3-methylbutyric acid","L-(+)-a-Aminoisovalerate","L-(+)-a-Aminoisovaleric acid","L-(+)-alpha-Aminoisovalerate","L-(+)-alpha-Aminoisovaleric acid","L-a-Amino-b-methylbutyrate","L-a-Amino-b-methylbutyric acid","L-alpha-Amino-beta-methylbutyrate","L-alpha-Amino-beta-methylbutyric acid","L-valine","valine"],"pathways":[{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Valine Biosynthesis","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YPD media","concentration":"2276.27692","concentration_units":"\u0026#181;M","error":"45.50769"},{"growth_media":"YPG media","concentration":"1838.74872","concentration_units":"\u0026#181;M","error":"36.88205"},{"growth_media":"SD media","concentration":"787.90769","concentration_units":"\u0026#181;M","error":"15.7641"},{"growth_media":"SG media","concentration":"875.65128","concentration_units":"\u0026#181;M","error":"17.54872"},{"growth_media":"M (molasses)","concentration":"525.27179","concentration_units":"\u0026#181;M","error":"10.41026"},{"growth_media":"MA (molasses)","concentration":"2801.54872","concentration_units":"\u0026#181;M","error":"55.91795"},{"growth_media":"MB (molasses)","concentration":"1225.73333","concentration_units":"\u0026#181;M","error":"24.38974"},{"growth_media":"MAB (molasses)","concentration":"2013.64103","concentration_units":"\u0026#181;M","error":"40.15385"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"2770.0","concentration_units":"\u0026#181;M","error":"139.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"3610.0","concentration_units":"\u0026#181;M","error":"664.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"10.0","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":4616942,"citation":"Ryan, E. D., Kohlhaw, G. B. (1974). \"Subcellular localization of isoleucine-valine biosynthetic enzymes in yeast.\" J Bacteriol 120:631-637."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":9748245,"citation":"Dickinson, J. R., Harrison, S. J., Hewlins, M. J. (1998). \"An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae.\" J Biol Chem 273:25751-25756."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" amine transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T21:01:35.000Z","updated_at":"2011-07-22T17:53:43.000Z","name":"Branched-chain-amino-acid aminotransferase, cytosolic","uniprot_id":"P47176","uniprot_name":"BCA2_YEAST","enzyme":true,"transporter":false,"gene_name":"BAT2","num_residues":376,"molecular_weight":"41624.39844","theoretical_pi":"7.36","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Involved in cell cycle regulation","reactions":[{"id":1152,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1678,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1712,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2045,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2358,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2359,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":2360,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":14458,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006970","source":"Smpdb"},{"id":14459,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006974","source":"Smpdb"},{"id":14460,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006978","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49648","genbank_protein_id":"1015897","gene_card_id":"BAT2","chromosome_location":"chromosome 10","locus":"YJR148W","synonyms":["BCAT","Protein TWT2"],"enzyme_classes":["2.6.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" branched-chain-amino-acid transaminase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" branched chain family amino acid metabolic process"}],"pfams":[{"name":"Aminotran_4","identifier":"PF01063"}],"pathways":[{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Leucine Degradation","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGACCTTGGCACCCCTAGACGCCTCCAAAGTTAAGATAACTACCACACAACATGCATCTAAGCCAAAACCGAACAGTGAGTTAGTGTTTGGCAAGAGCTTCACGGACCACATGTTAACTGCGGAATGGACAGCTGAAAAAGGGTGGGGTACCCCAGAGATTAAACCTTATCAAAATCTGTCTTTAGACCCTTCCGCGGTGGTTTTCCATTATGCTTTTGAGCTATTCGAAGGGATGAAGGCTTACAGAACGGTGGACAACAAAATTACAATGTTTCGTCCAGATATGAATATGAAGCGCATGAATAAGTCTGCTCAGAGAATCTGTTTGCCAACGTTCGACCCAGAAGAGTTGATTACCCTAATTGGGAAACTGATCCAGCAAGATAAGTGCTTAGTTCCTGAAGGAAAAGGTTACTCTTTATATATCAGGCCTACATTAATCGGCACTACGGCCGGTTTAGGGGTTTCCACGCCTGATAGAGCCTTGCTATATGTCATTTGCTGCCCTGTGGGTCCTTATTACAAAACTGGATTTAAGGCGGTCAGACTGGAAGCCACTGATTATGCCACAAGAGCTTGGCCAGGAGGCTGTGGTGACAAGAAACTAGGTGCAAACTACGCCCCCTGCGTCCTGCCACAATTGCAAGCTGCTTCAAGGGGTTACCAACAAAATTTATGGCTATTTGGTCCAAATAACAACATTACTGAAGTCGGCACCATGAATGCTTTTTTCGTGTTTAAAGATAGTAAAACGGGCAAGAAGGAACTAGTTACTGCTCCACTAGACGGTACCATTTTGGAAGGTGTTACTAGGGATTCCATTTTAAATCTTGCTAAAGAAAGACTCGAACCAAGTGAATGGACCATTAGTGAACGCTACTTCACTATAGGCGAAGTTACTGAGAGATCCAAGAACGGTGAACTACTTGAAGCCTTTGGTTCTGGTACTGCTGCGATTGTTTCTCCCATTAAGGAAATCGGCTGGAAAGGCGAACAAATTAATATTCCGTTGTTGCCCGGCGAACAAACCGGTCCATTGGCCAAAGAAGTTGCACAATGGATTAATGGAATCCAATATGGCGAGACTGAGCATGGCAATTGGTCAAGGGTTGTTACTGATTTGAACTGA","protein_sequence":"MTLAPLDASKVKITTTQHASKPKPNSELVFGKSFTDHMLTAEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKCLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNNNITEVGTMNAFFVFKDSKTGKKELVTAPLDGTILEGVTRDSILNLAKERLEPSEWTISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPIKEIGWKGEQINIPLLPGEQTGPLAKEVAQWINGIQYGETEHGNWSRVVTDLN"},{"created_at":"2011-05-24T21:03:21.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Leu/Val/Ile amino-acid permease","uniprot_id":"P38084","uniprot_name":"BAP2_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP2","num_residues":609,"molecular_weight":"67669.60156","theoretical_pi":"8.22","general_function":"Involved in transport","specific_function":"Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;124-144;174-194;211-231;236-256;290-310;329-349;375-395;428-448;452-472;501-521;537-557","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z35937","genbank_protein_id":"536316","gene_card_id":"BAP2","chromosome_location":"chromosome 2","locus":"YBR068C","synonyms":["Branched-chain amino-acid permease 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" amine transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGCTATCTTCAGAAGATTTTGGATCTTCTGGGAAAAAGGAAACTTCTCCTGATTCGATATCGATACGTTCCTTTAGTGCCGGGAATAATTTCCAATCATCATCAAGTGAGAAAACTTATTCTAAGCAAAAATCCGGGAGTGACAAACTTATACATAGATTTGCGGATTCATTCAAAAGAGCCGAGGGTAGCACTACAAGAACTAAGCAAATAAATGAAAATACGTCTGATTTAGAGGATGGCGTTGAGTCTATCACGTCGGATTCCAAGTTGAAAAAGTCCATGAAGTCGCGCCATGTTGTCATGATGTCTTTAGGGACAGGTATTGGGACTGGTCTTTTGGTAGCTAATGCAAAAGGTCTACATTACGGTGGTCCTGCTGCGCTAATAATTGGTTACATCTTGGTTTCTTTCGAGACGTACTTCATGATCCAAGCTGCAGGTGAGATGGCGGTAACCTATCCGACTTTACCAGCAAATTTCAACGCATACTCCTCCATATTCATTTCCAAATCATTTGGATTCGCCACAGTATGGCTTTACTGTTTCCAATGGCTAACGGTTTTGCCTTTAGAGTTAATAACCGCGTCTATGACTATTCAATTTGGGAATGATAAAATAAATCCGGACATTTATATTCTTATTTTCTATGTTTTCTTAGTATTCATTCATTTCTTCGGTGTAAAAGCCTATGGTGAAACGGAATTCATCTTCAATTGCTGTAAAATTTTAATGATTGCAGGTTTCATTATTCTTTCTATTGTTATCAACTGTGGTGGGGCCGGAAATGACGGTTATATCGGGGCCACTTATTGGCATAATCCAGGTGCTTTTGCAGGTGACACATCGATTGGTAGGTTCAAAAACGTTTGCTATATTTTAGTTACTGCTTACTTCTCCTTTGGTGGTATGGAATTATTTGCACTAAGTGTTCAGGAACAGTCTAACCCTAGAAAATCTACTCCGGTGGCAGCCAAGAGAAGCATTTATCGTATCGTTGTGATTTATCTTTTGACTATGATCCTCATTGGATTCAATGTTCCATATAATGATGACCAACTAATGGGCGCAGGCGGATCCGCTACACATGCATCTCCCTATGTCTTAGCCGCTTCTATTCACGGTGTGAAAATTGTTCCACATATTATCAACGCTGTTATTTTGATTTCTGTGGTTTCAGTGGCAAATTCCTCTTTGTATGCTGGTCCAAGACTGATTTGCTCTTTGGCCCAACAAGGCTACGCACCCAAGTTTTTAGATTACGTTGACAGAGAGGGCAGGCCCTTGAGAGCTCTTATTGTGTGTTGCGTTTTCGGCGTCATTGCTTTTGTTGCAGCTTCATCAAAGGAAGAGATCGTGTTTACATGGTTAGCAGCTATCGCAGGCTTGAGTGAATTATTCACATGGACTTCCATAATGTTGTCCCATCTGCGATTCAGACAAGCAATGAAAGTACAGGGAAGGTCTCTAGACGAGTTGGGATACAAGGCCACAACAGGGATTTGGGGTTCCATATACGGTGTCTTTTTTAATATTTTAGTCTTTGTTGCCCAATTTTGGGTAGCATTGGCCCCCTTAGGTAATGGGGGCAAATGCGATGCGGAATCCTTCTTTCAAAATTATTTAGCTTTTCCAATATGGTTGGCCTTTTACTTCGGATATATGGTTTACAACCGAGATTTTACGCTATTAAATCCCCTCGACAAGATTGACCTTGACTTCCACAGACGCATTTATGATCCAGAGCTAATGAGACAAGAGGACGAAGAAAATAAAGAAAAACTAAGGAATATGTCTTTGATGAGAAAAGCTTATCATTTCTGGTGTTAA","protein_sequence":"MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKRAEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLHYGGPAALIIGYILVSFETYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWLYCFQWLTVLPLELITASMTIQFGNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNCCKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFSFGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGSATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLDYVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFRQAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQNYLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSLMRKAYHFWC"},{"created_at":"2011-05-24T21:03:55.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine/tyrosine/tryptophan amino-acid permease 1","uniprot_id":"P38085","uniprot_name":"TAT1_YEAST","enzyme":false,"transporter":true,"gene_name":"TAT1","num_residues":619,"molecular_weight":"68756.89844","theoretical_pi":"7.8","general_function":"Involved in transport","specific_function":"High-affinity transport of valine and tyrosine. Low- affinity transport of tryptophan. Can also transport L-cysteine","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;123-143;173-193;205-225;234-254;282-302;321-341;369-389;423-443;447-467;500-520;530-550","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U10503","genbank_protein_id":"558077","gene_card_id":"TAT1","chromosome_location":"chromosome 2","locus":"YBR069C","synonyms":["Tyrosine and tryptophan amino acid transporter 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" amine transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGACGATAGTGTCAGTTTCATTGCCAAAGAGGCCAGTCCAGCACAATATTCGCACAGTTTGCATGAAAGAACACACAGTGAAAAACAAAAGAGAGACTTTACAATAACAGAAAAACAAGATGAGGTATCTGGACAAACAGCGGAGCCTCGAAGGACGGACAGCAAATCCATATTACAGAGGAAATGCAAAGAATTCTTCGACTCTTTTAAAAGGCAGCTGCCACCAGACCGTAATTCCGAACTAGAGTCCCAAGAAAAAAACAACCTGACAAAGTCGATCAAATCTCGTCACTTAGTCATGATCAGTCTCGGTACCGGTATAGGTACTGGTTTACTGGTCGGTAATGGTCAGGTGCTGGGAACAGCTGGTCCTGCCGGGTTAGTCCTTGGTTACGGAATAGCATCGATCATGCTTTACTGTATCATCCAAGCGGCAGGCGAGTTAGGTCTCTGTTATGCAGGACTAACCGGCAATTACACCAGATATCCTTCTATTTTAGTCGACCCTTCGTTGGGTTTTGCAGTTTCTGTGGTTTACACCATTCAATGGCTAACTGTTCTGCCCTTACAATTGGTCACTGCGGCAATGACAGTTAAGTACTGGACGAGTGTAAATGCAGACATCTTTGTTGCCGTGGTTTTCGTTTTTGTAATTATCATTAATCTATTTGGGTCCAGAGGCTATGCTGAAGCCGAGTTCATTTTCAATTCCTGTAAGATATTGATGGTAATCGGATTCGTCATTCTGGCGATTATCATCAATTGTGGGGGTGCAGGTGACAGAAGATACATCGGTGCTGAGTACTGGCACAATCCTGGTCCATTTGCCCACGGTTTCAAAGGTGTATGTACGGTTTTCTGTTATGCTGCATTCAGCTACGGTGGAATTGAAGTTCTACTTCTATCTGCCGCTGAGCAGGAAAACCCAACAAAATCTATTCCCAATGCCTGCAAAAAAGTGGTATACCGTATTCTGCTGATTTACATGCTCACCACCATTTTGGTTTGCTTTCTTGTTCCATACAACAGTGACGAATTATTAGGGTCTAGTGACTCCTCTGGATCCCATGCCTCCCCATTTGTCATTGCTGTTGCATCACATGGTGTCAAAGTTGTGCCTCACTTTATAAATGCTGTTATTTTGATTTCTGTCATTTCTGTTGCAAACTCTTCGTTATATTCTGGGCCAAGATTGTTATTATCATTGGCAGAACAAGGCGTCTTACCTAAATGCTTAGCATATGTTGATAGAAACGGCAGGCCTTTACTTTGTTTTTTTGTTTCCCTTGTCTTTGGATGCATTGGGTTTGTAGCCACTAGTGACGCTGAAGAACAGGTTTTCACCTGGTTATTGGCAATTTCTAGTCTTTCGCAATTATTTATCTGGATGTCAATGTCCTTGTCACATATAAGATTTAGAGATGCCATGGCAAAGCAAGGTCGTTCGATGAACGAAGTTGGATACAAAGCACAAACTGGCTATTGGGGTTCATGGCTTGCAGTTTTAATTGCAATCTTCTTCCTTGTGTGCCAGTTCTGGGTAGCCATCGCACCTGTTAATGAACATGGAAAACTTAACGTCAAAGTGTTTTTCCAAAATTATTTGGCAATGCCCATCGTTTTGTTTGCCTATTTTGGTCACAAGATATACTTCAAATCATGGAGCTTTTGGATTCCAGCCGAAAAAATTGATTTGGACTCACATAGAAACATATTTGTGTCTCCATCGCTTACAGAGATCGACAAAGTTGACGATAACGATGATCTTAAAGAGTATGAAAATTCAGAATCGTCGGAAAATCCAAACAGTTCGCGTTCAAGAAAGTTTTTTAAGAGGATGACCAATTTCTGGTGCTAA","protein_sequence":"MDDSVSFIAKEASPAQYSHSLHERTHSEKQKRDFTITEKQDEVSGQTAEPRRTDSKSILQRKCKEFFDSFKRQLPPDRNSELESQEKNNLTKSIKSRHLVMISLGTGIGTGLLVGNGQVLGTAGPAGLVLGYGIASIMLYCIIQAAGELGLCYAGLTGNYTRYPSILVDPSLGFAVSVVYTIQWLTVLPLQLVTAAMTVKYWTSVNADIFVAVVFVFVIIINLFGSRGYAEAEFIFNSCKILMVIGFVILAIIINCGGAGDRRYIGAEYWHNPGPFAHGFKGVCTVFCYAAFSYGGIEVLLLSAAEQENPTKSIPNACKKVVYRILLIYMLTTILVCFLVPYNSDELLGSSDSSGSHASPFVIAVASHGVKVVPHFINAVILISVISVANSSLYSGPRLLLSLAEQGVLPKCLAYVDRNGRPLLCFFVSLVFGCIGFVATSDAEEQVFTWLLAISSLSQLFIWMSMSLSHIRFRDAMAKQGRSMNEVGYKAQTGYWGSWLAVLIAIFFLVCQFWVAIAPVNEHGKLNVKVFFQNYLAMPIVLFAYFGHKIYFKSWSFWIPAEKIDLDSHRNIFVSPSLTEIDKVDDNDDLKEYENSESSENPNSSRSRKFFKRMTNFWC"},{"created_at":"2011-05-24T21:05:56.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine amino-acid permease","uniprot_id":"P41815","uniprot_name":"BAP3_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP3","num_residues":604,"molecular_weight":"67364.39844","theoretical_pi":"8.28","general_function":"Involved in transport","specific_function":"Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;120-140;170-190;207-227;239-259;285-305;324-344;378-398;424-444;450-470;503-523;532-552","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z49209","genbank_protein_id":"798899","gene_card_id":"BAP3","chromosome_location":"chromosome 4","locus":"YDR046C","synonyms":["Branched-chain amino-acid permease 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" amine transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCAGATCCTATAGTAACGTCTTCCAAAATGGAAAAAAGTGCAGAGTTTGAAGTAACAGACTCTGCTTTATATAATAACTTCAATACATCAACAACAGCTTCACTAACTCCGGAGATTAAGGAACATTCTGAGGAATCTCGCAATGGGTTAGTTCACAGATTCGTCGACTCATTCAGAAGAGCCGAAAGCCAACGTTTAGAAGAAGACAATGACTTGGAGGATGGTACCAAATCGATGAAATCTAATAACCACTTAAAAAAGTCAATGAAATCTAGACATGTTGTAATGATGTCTTTAGGTACAGGGATAGGAACAGGTCTTCTAGTTGCCAACGCCAAAGGTTTGAGTCTTGCAGGCCCGGGGTCTTTAGTCATCGGTTACGTTATGGTGTCCTTCGTCACGTATTTTATGGTCCAAGCGGCTGGTGAGATGGGTGTCACTTATCCGACGCTTCCAGGTAACTTCAATGCATACAATTCAATCTTTATTTCAAAGTCGTTTGGGTTCGCGACCACTTGGTTATTTTGCATTCAGTGGTTAACTGTGCTACCGTTGGAATTGATTACTTCTTCCATGACCGTCAAGTACTGGAATGACACAATTAATGCTGATGTATTCATTGTCATTTTCTATGTGTTTTTATTGTTTATCCACTTTTTTGGTGTTAAGGCATACGGTGAAACGGAATTTATCTTCAATTCCTGTAAGATATTGATGGTTGCAGGATTCATTATTTTATCAGTCGTCATCAATTGTGGGGGAGCCGGTGTGGACGGCTATATTGGCGGCAAATATTGGCGCGACCCTGGTTCATTTGCAGAAGGCAGCGGTGCCACTCGTTTCAAAGGGATATGTTATATTCTAGTATCTGCATATTTCTCCTTCGGTGGTATTGAATTATTTGTTCTTTCCATCAATGAGCAGTCTAACCCTAGAAAATCCACTCCTGTAGCCGCGAAGAGAAGTGTATATCGTATTTTGATCATTTATTTGCTGACAATGATTCTAATTGGGTTCAATGTTCCTCACAATAACGATCAATTGATGGGTTCCGGTGGCTCCGCAACGCACGCTTCACCATATGTCTTGGCAGCCTCTATTCACAAGGTTAGGGTCATCCCCCATATCATTAATGCTGTTATTTTGATATCAGTCATCTCTGTTGCGAACTCTGCCCTTTATGCCGCACCGAGATTAATGTGTTCCTTGGCTCAACAGGGCTATGCTCCAAAATTTTTGAACTATATTGATAGGGAGGGAAGACCTTTAAGGGCCTTGGTAGTGTGCTCTCTTGTTGGTGTCGTTGGCTTCGTCGCCTGTTCTCCACAGGAAGAGCAAGCATTTACATGGTTGGCAGCCATTGCAGGTTTGAGTGAACTTTTCACATGGTCAGGCATTATGCTTTCACACATTCGATTCAGAAAAGCGATGAAAGTCCAAGGAAGATCACTTGATGAAGTCGGCTATAAGGCCAATACCGGTATATGGGGTTCATACTATGGGGTTTTTTTCAATATGCTTGTCTTTATGGCCCAATTTTGGGTCGCACTGTCTCCAATAGGAAATGGCGGAAAGTGTGATGCTCAGGCATTCTTCGAGAGTTATCTGGCTGCCCCGCTATGGATATTCATGTATGTTGGATACATGGTTTACAAAAGAGATTTTACCTTTTTAAACCCACTGGACAAGATCGACTTGGACTTTCATAGAAGAGTTTACGACCCTGAAATAATGAGGCAGGAGGACGAAGAAAATAAAGAAAGGTTAAAGAACTCTTCAATATTCGTCAGAGTCTACAAATTTTGGTGTTAG","protein_sequence":"MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFRRAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAGPGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQWLTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILMVAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIELFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHASPYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDREGRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKVQGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAPLWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVYKFWC"},{"created_at":"2011-05-24T21:06:51.000Z","updated_at":"2011-07-22T17:53:43.000Z","name":"Branched-chain-amino-acid aminotransferase, mitochondrial","uniprot_id":"P38891","uniprot_name":"BCA1_YEAST","enzyme":true,"transporter":false,"gene_name":"BAT1","num_residues":393,"molecular_weight":"43595.69922","theoretical_pi":"9.27","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1","reactions":[{"id":1152,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1678,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1712,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2046,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2358,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2359,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":2360,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":14455,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006969","source":"Smpdb"},{"id":14456,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006973","source":"Smpdb"},{"id":14457,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006977","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY558111","genbank_protein_id":"45270112","gene_card_id":"BAT1","chromosome_location":"chromosome 8","locus":"YHR208W","synonyms":["BCAT","Protein ECA39","Protein TWT1"],"enzyme_classes":["2.6.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" branched-chain-amino-acid transaminase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" branched chain family amino acid metabolic process"}],"pfams":[{"name":"Aminotran_4","identifier":"PF01063"}],"pathways":[{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Leucine Degradation","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGTTGCAGAGACATTCCTTGAAGTTGGGGAAATTCTCCATCAGAACACTCGCTACTGGTGCCCCATTAGATGCATCCAAACTAAAAATTACTAGAAACCCAAATCCATCCAAGCCAAGACCAAATGAAGAATTAGTGTTCGGCCAGACATTCACCGATCATATGTTGACCATTCCTTGGTCAGCCAAAGAAGGGTGGGGCACTCCACACATCAAGCCTTACGGTAATCTTTCTCTTGACCCATCTGCTTGTGTATTCCATTATGCATTTGAATTATTTGAAGGTTTGAAAGCCTACAGAACTCCTCAAAATACTATCACCATGTTCCGTCCGGATAAGAACATGGCCCGTATGAACAAGTCTGCCGCTAGAATTTGTTTGCCAACTTTCGAATCTGAAGAATTGATCAAACTTACCGGGAAATTGATCGAACAAGATAAACACTTGGTTCCTCAAGGTAATGGTTACTCATTATACATCAGACCAACAATGATTGGTACATCCAAGGGTTTAGGTGTTGGCACTCCCTCCGAGGCTCTTCTTTATGTTATTACTTCTCCAGTCGGTCCTTATTATAAGACTGGTTTCAAAGCCGTACGTCTTGAAGCAACAGACTATGCTACAAGAGCTTGGCCAGGTGGTGTTGGCGACAAAAAATTGGGTGCTAACTATGCCCCATGCATCTTACCTCAACTACAAGCTGCCAAAAGAGGGTACCAACAAAATCTATGGTTGTTCGGCCCAGAAAAGAACATCACTGAGGTTGGTACTATGAACGTGTTCTTCGTTTTCCTCAACAAAGTCACTGGCAAGAAGGAATTGGTTACCGCTCCATTAGATGGTACCATTTTAGAAGGTGTTACCAGAGACTCTGTTTTAACATTGGCTCGTGACAAACTAGATCCTCAAGAATGGGACATCAACGAGCGTTATTACACTATTACTGAAGTCGCCACTAGAGCAAAACAAGGTGAACTATTAGAAGCCTTCGGTTCTGGTACTGCTGCTGTCGTTTCACCTATCAAGGAAATTGGCTGGAACAACGAAGATATTCATGTTCCACTATTGCCTGGTGAACAATGTGGTGCATTGACCAAGCAAGTTGCTCAATGGATTGCTGATATCCAATACGGTAGAGTCAATTATGGTAACTGGTCAAAAACTGTTGCCGACTTGAACTAA","protein_sequence":"MLQRHSLKLGKFSIRTLATGAPLDASKLKITRNPNPSKPRPNEELVFGQTFTDHMLTIPWSAKEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPEKNITEVGTMNVFFVFLNKVTGKKELVTAPLDGTILEGVTRDSVLTLARDKLDPQEWDINERYYTITEVATRAKQGELLEAFGSGTAAVVSPIKEIGWNNEDIHVPLLPGEQCGALTKQVAQWIADIQYGRVNYGNWSKTVADLN"},{"created_at":"2011-05-26T17:45:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"General amino acid permease AGP1","uniprot_id":"P25376","uniprot_name":"AGP1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP1","num_residues":633,"molecular_weight":"69670.70313","theoretical_pi":"6.97","general_function":"Involved in transport","specific_function":"Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source","reactions":[],"signal_regions":"None","transmembrane_regions":"125-145;149-169;198-218;232-252;261-281;314-334;353-373;403-425;453-473;478-498;532-552;561-581","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"AGP1","chromosome_location":"chromosome 3","locus":"YCL025C","synonyms":["Asparagine/glutamine permease"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" amine transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCGAAGTCTCTATACGAACTGAAAGACTTGAAAAATAGCTCCACAGAAATACATGCCACGGGGCAGGATAATGAAATTGAATATTTCGAAACAGGCTCCAATGACCGTCCATCCTCACAACCTCATTTAGGTTACGAACAGCATAACACTTCTGCCGTGCGTAGGTTTTTCGACTCCTTTAAAAGAGCGGATCAGGGTCCACAGGATGAAGTAGAAGCAACACAAATGAACGATCTTACGTCGGCTATCTCACCTTCTTCTAGACAGGCTCAAGAACTAGAAAAAAATGAAAGTTCGGACAACATAGGCGCTAATACAGGTCATAAGTCGGACTCGCTGAAGAAAACCATTCAGCCTAGACATGTTCTGATGATTGCGTTGGGTACGGGTATCGGTACTGGGTTATTGGTCGGTAACGGTACCGCGTTGGTTCATGCGGGTCCAGCTGGACTACTTATTGGTTACGCTATTATGGGTTCTATCTTGTACTGTATTATTCAAGCATGTGGTGAAATGGCGCTAGTGTATAGTAACTTGACTGGTGGCTACAATGCATACCCCAGTTTCCTTGTGGATGATGGTTTTGGGTTTGCAGTCGCTTGGGTTTATTGTTTGCAATGGCTGTGTGTGTGTCCTCTGGAATTGGTGACCGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTGTTCGTCATTATTTTCTATGTTTTGGTGATTACTATTAATATTTTCGGTGCTCGTGGTTATGCAGAAGCTGAGTTCTTCTTCAACTGTTGCAAAATTTTGATGATGACTGGGTTCTTCATTCTTGGTATTATCATCGATGTTGGTGGCGCTGGTAATGATGGTTTTATTGGTGGTAAATACTGGCACGATCCGGGCGCTTTCAATGGTAAACATGCCATTGACAGATTTAAAGGTGTTGCTGCAACATTAGTGACTGCTGCTTTTGCCTTTGGTGGTTCAGAGTTTATTGCCATCACCACTGCAGAACAATCTAATCCAAGAAAGGCCATTCCAGGTGCGGCCAAACAAATGATCTACAGAATCTTATTCCTATTCTTGGCTACCATTATTCTACTGGGTTTCTTGGTGCCATACAATTCCGATCAATTATTGGGTTCTACCGGTGGTGGTACTAAAGCCTCGCCATATGTCATTGCTGTTGCATCCCACGGTGTCCGTGTCGTCCCACACTTCATTAACGCCGTTATTCTACTTTCCGTGCTGTCCATGGCTAACTCCTCCTTCTACTCCAGTGCTCGTTTATTTTTAACTCTATCCGAGCAAGGTTACGCTCCTAAGGTTTTCTCCTACATCGACAGAGCCGGTAGACCATTGATTGCCATGGGTGTTTCTGCATTGTTTGCCGTTATTGCCTTCTGTGCTGCATCTCCCAAGGAAGAACAAGTTTTCACTTGGTTATTGGCCATTTCTGGTTTGTCTCAGCTTTTCACATGGACTGCCATTTGTTTATCCCATCTTAGATTTAGAAGAGCCATGAAAGTCCAAGGGAGATCTCTTGGAGAATTGGGTTTCAAATCTCAAACTGGTGTTTGGGGATCTGCCTACGCTTGCATTATGATGATTTTAATTCTTATTGCCCAATTTTGGGTCGCTATCGCCCCCATTGGTGAAGGTAAGCTGGATGCACAAGCCTTTTTCGAAAACTACTTGGCTATGCCAATCTTGATTGCACTTTATGTCGGCTACAAGGTCTGGCACAAGGATTGGAAACTGTTCATCAGGGCAGACAAGATCGACCTAGATTCTCATAGACAAATCTTTGATGAAGAATTAATCAAGCAAGAAGACGAAGAATATAGGGAACGTTTGAGGAACGGACCTTATTGGAAAAGGGTCGTTGCCTTCTGGTGTTAA","protein_sequence":"MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC"},{"created_at":"2011-05-26T18:35:57.000Z","updated_at":"2011-05-27T15:01:04.000Z","name":"Valyl-tRNA synthetase, mitochondrial","uniprot_id":"P07806","uniprot_name":"SYV_YEAST","enzyme":true,"transporter":false,"gene_name":"VAS1","num_residues":1104,"molecular_weight":"125769.0","theoretical_pi":"6.96","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)","reactions":[{"id":2047,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2540,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm","altext":"ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"J02719","genbank_protein_id":"173164","gene_card_id":"VAS1","chromosome_location":"chromosome 7","locus":"YGR094W","synonyms":["Valine--tRNA ligase","ValRS"],"enzyme_classes":["6.1.1.9"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" valine-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" valyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"}],"pfams":[{"name":"Anticodon_1","identifier":"PF08264"},{"name":"tRNA-synt_1","identifier":"PF00133"}],"pathways":[{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"}],"gene_sequence":"ATGAATAAGTGGTTAAACACATTATCTAAGACATTCACTTTTCGGCTTTTGAACTGTCATTATAGGCGATCATTACCACTTTGTCAAAACTTTTCTCTGAAGAAGTCGTTAACTCATAATCAAGTCAGGTTCTTTAAAATGAGCGATCTTGATAATTTGCCTCCAGTTGACCCAAAGACTGGTGAGGTCATCATTAATCCGTTAAAGGAAGATGGCTCTCCAAAGACTCCTAAGGAAATTGAAAAAGAGAAGAAAAAGGCTGAAAAACTGTTAAAGTTCGCTGCCAAACAAGCTAAAAAAAATGCTGCTGCCACCACAGGTGCATCTCAAAAGAAACCTAAGAAAAAGAAGGAAGTTGAGCCAATCCCTGAATTTATTGACAAAACTGTTCCAGGTGAGAAAAAAATCTTAGTATCCTTGGATGATCCGGCTTTAAAAGGTTATAACCCTGCTAACGTTGAAAGTTCTTGGTATGACTGGTGGATCAAGACTGGTGTTTTTGAACCTGAATTTACCGCTGATGGTAAGGTTAAACCAGAAGGTGTATTTTGCATTCCAGCACCTCCACCAAACGTCACTGGTGCCTTACATATTGGTCATGCTTTGACTATTGCTATCCAAGATTCTTTGATCAGATATAACAGAATGAAAGGTAAAACTGTCTTATTCTTGCCAGGTTTCGACCATGCTGGTATTGCTACTCAGTCCGTTGTGGAGAAGCAAATCTGGGCTAAGGACAGAAAGACTAGACATGACTATGGAAGAGAAGCTTTTGTTGGTAAGGTCTGGGAATGGAAAGAGGAATACCATAGCAGAATTAAGAACCAAATTCAAAAATTGGGGGCTTCTTATGATTGGAGCCGCGAAGCTTTCACTTTGAGTCCAGAATTGACCAAGTCTGTTGAAGAAGCTTTTGTTAGACTACATGATGAAGGTGTTATTTATCGTGCGTCCAGATTAGTTAATTGGTCTGTTAAATTGAATACCGCTATCTCTAATTTGGAAGTCGAAAATAAGGACGTTAAAAGTAGAACGCTTTTATCAGTCCCAGGCTATGATGAAAAGGTTGAATTTGGTGTTTTAACATCATTTGCTTATCCAGTTATCGGTAGCGATGAAAAACTGATCATTGCTACAACTAGACCTGAAACTATATTTGGTGATACTGCCGTTGCAGTTCATCCTGATGATGACCGTTACAAACACTTGCATGGTAAGTTCATCCAACATCCTTTCTTACCAAGAAAAATTCCAATTATCACCGACAAGGAAGCTGTTGACATGGAATTCGGTACTGGTGCCGTTAAGATCACTCCAGCCCATGACCAAAACGATTACAATACCGGTAAGCGTCACAATTTGGAATTCATCAATATTTTGACTGACGATGGTTTATTAAACGAGGAGTGTGGTCCAGAGTGGCAAGGCATGAAAAGGTTTGATGCCAGAAAGAAGGTCATTGAGCAGCTGAAGGAAAAGAACCTATACGTTGGCCAAGAAGATAATGAAATGACCATTCCAACTTGTTCCAGATCTGGTGACATTATTGAACCTTTATTGAAACCTCAATGGTGGGTTTCTCAAAGTGAAATGGCCAAAGATGCTATTAAGGTTGTTAAGGATGGTCAAATTACCATCACCCCCAAATCTTCTGAGGCTGAATATTTCCATTGGTTGGGTAACATCCAAGATTGGTGTATTTCCAGACAATTATGGTGGGGTCATCGTTGTCCAGTTTACTTTATTAACATCGAAGGCGAAGAACACGATAGAATTGATGGTGACTATTGGGTTGCTGGTAGGAGCATGGAGGAAGCTGAAAAGAAGGCTGCTGCCAAATACCCTAATTCCAAATTTACTCTGGAACAAGATGAAGATGTTTTAGACACCTGGTTCTCGTCCGGTTTGTGGCCTTTCTCCACTTTGGGTTGGCCAGAAAAGACTAAAGACATGGAAACTTTTTACCCATTTTCTATGTTGGAAACTGGTTGGGATATTCTTTTCTTCTGGGTTACTAGAATGATTCTATTGGGCTTAAAATTGACCGGTTCAGTTCCATTCAAGGAAGTTTTCTGCCACTCTTTAGTCCGTGACGCTCAAGGTCGTAAGATGTCTAAATCTTTAGGTAATGTTATTGACCCACTAGACGTTATTACTGGTATTAAGTTGGATGATTTGCATGCAAAATTATTACAAGGTAACTTAGATCCAAGAGAAGTTGAAAAAGCTAAGATCGGTCAAAAGGAATCCTACCCTAACGGTATTCCTCAATGTGGTACCGATGCTATGAGGTTTGCATTATGTGCTTATACCACTGGTGGTCGTGATATTAACTTAGATATCTTACGTGTCGAAGGTTACAGAAAGTTCTGTAACAAAATCTACCAAGCTACCAAGTTTGCATTGATGAGACTCGGTGACGATTATCAACCACCTGCCACTGAAGGTCTATCAGGTAACGAATCCTTGGTTGAAAAATGGATCTTGCACAAGCTGACTGAAACCTCGAAAATTGTCAATGAAGCTCTAGATAAACGTGACTTCTTGACGTCCACTAGCAGTATTTACGAATTCTGGTATTTGATTTGTGATGTTTACATCGAGAACTCTAAATACTTGATTCAAGAAGGCTCTGCTATTGAAAAGAAGTCCGCAAAGGATACATTGTATATCTTGCTGGACAACGCTTTGAAATTAATCCACCCATTCATGCCATTCATTTCTGAAGAAATGTGGCAAAGACTTCCAAAGCGTTCCACTGAGAAGGCTGCCTCAATTGTAAAAGCTTCTTATCCAGTTTACGTATCTGAGTACGATGATGTCAAATCGGCCAACGCTTACGACTTGGTCTTGAACATTACCAAAGAAGCTCGTTCCTTGTTATCTGAGTACAATATTTTGAAGAATGGTAAGGTTTTCGTTGAATCTAACCACGAGGAATACTTCAAAACTGCTGAAGATCAGAAAGATTCTATTGTCTCGTTGATCAAGGCCATCGACGAAGTCACTGTTGTTCGTGATGCTTCCGAAATTCCAGAAGGTTGCGTATTGCAATCTGTTAACCCAGAAGTCAATGTACATCTTCTCGTCAAGGGACACGTTGATATTGATGCTGAAATTGCGAAAGTTCAAAAGAAACTTGAAAAGGCTAAAAAATCCAAGAACGGTATTGAACAAACCATTAACAGTAAGGATTACGAAACAAAGGCTAATACACAGGCCAAGGAAGCCAATAAAAGCAAGCTGGATAACACTGTTGCCGAAATCGAAGGTTTGGAAGCTACTATTGAAAACTTGAAGCGTTTGAAATTGTAG","protein_sequence":"MNKWLNTLSKTFTFRLLNCHYRRSLPLCQNFSLKKSLTHNQVRFFKMSDLDNLPPVDPKTGEVIINPLKEDGSPKTPKEIEKEKKKAEKLLKFAAKQAKKNAAATTGASQKKPKKKKEVEPIPEFIDKTVPGEKKILVSLDDPALKAYNPANVESSWYDWWIKTGVFEPEFTADGKVKPEGVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYPVIGSDEKLIIATTRPETIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGLLNEECGPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSMEEAEKKAAAKYPNSKFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKESYPNGIPQCGTDAMRFALCAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEFWYLICDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEYNILKNGKVFVESNHEEYFKTAEDQKDSIVSLIKAIDEVTVVRDASEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENLKRLKL"}]}