2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) (YMDB11846)

Identification
YMDB IDYMDB11846
Name2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0)
SpeciesSaccharomyces cerevisiae
StrainBrewer's yeast
Description2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails, instead of the usual two. 2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) contains two chains of (9Z-tetradecenoyl) at the C1 and C2 positions, one chain of hexadecanoic acid at the C3 position, one chain of at the C4 position. MLCL is present in eukaryotes as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from a cardiolipin results in generation of monolysocardiolipin (MLCL). MLCL has been used as an inter­mediate in the synthesis of spin-labeled CL to study the interaction of CL with mitochondrial enzymes. Because a role for MLCL has been suggested in apoptosis, this molecule has been used to study its interaction with various enzymes involved in lipid remodeling and apoptosis. There are two species of monolysocardiolipins, 1-MLCL which is missing a fatty acid in position R1 the and 2-MLCL which is missing a fatty acid in position R4.
Structure
Thumb
MOLSDFPDBSMILESInChI
SynonymsNot Available
CAS numberNot Available
WeightAverage: 1055.315
Monoisotopic: 1054.648661136
InChI KeyKFHRTIGAYXKERM-CMQMAEFISA-N
InChIInChI=1S/C53H100O16P2/c1-4-7-10-13-16-19-22-23-26-28-30-33-36-39-51(56)63-42-48(54)43-65-70(59,60)66-44-49(55)45-67-71(61,62)68-47-50(69-53(58)41-38-35-32-29-25-21-18-15-12-9-6-3)46-64-52(57)40-37-34-31-27-24-20-17-14-11-8-5-2/h14-15,17-18,48-50,54-55H,4-13,16,19-47H2,1-3H3,(H,59,60)(H,61,62)/b17-14-,18-15-/t48-,49-,50-/m1/s1
IUPAC Name[(2R)-2,3-bis[(9Z)-tetradec-9-enoyloxy]propoxy][(2R)-3-({[(2R)-3-(hexadecanoyloxy)-2-hydroxypropoxy](hydroxy)phosphoryl}oxy)-2-hydroxypropoxy]phosphinic acid
Traditional IUPAC Name(2R)-2,3-bis[(9Z)-tetradec-9-enoyloxy]propoxy((2R)-3-{[(2R)-3-(hexadecanoyloxy)-2-hydroxypropoxy(hydroxy)phosphoryl]oxy}-2-hydroxypropoxy)phosphinic acid
Chemical FormulaC53H100O16P2
SMILES[H][C@@](O)(COC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OC[C@@]([H])(O)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCC\C=C/CCCC)OC(=O)CCCCCCC\C=C/CCCC
Chemical Taxonomy
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.00049 g/LALOGPS
logP7.77ALOGPS
logP14.29ChemAxon
logS-6.3ALOGPS
pKa (Strongest Acidic)1.59ChemAxon
pKa (Strongest Basic)-3.4ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area230.88 ŲChemAxon
Rotatable Bond Count56ChemAxon
Refractivity280.34 m³·mol⁻¹ChemAxon
Polarizability121.43 ųChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • Mitochondrion membrane
Organoleptic PropertiesNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(14:1(9Z)/14:1(9Z)/16:0/16:1(11Z))PW010589 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:1(9Z)/14:1(9Z)/16:0/18:0)PW010591 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:1(9Z)/14:1(9Z)/16:0/18:1(11Z))PW010592 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:1(9Z)/14:1(9Z)/16:0/18:1(9Z))PW010593 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:1(9Z)/14:1(9Z)/16:0/20:0)PW010594 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB Reactions
2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) → CL(14:1(9Z)/14:1(9Z)/16:0/16:1(11Z))
2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) → CL(14:1(9Z)/14:1(9Z)/16:0/18:0)
2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) → CL(14:1(9Z)/14:1(9Z)/16:0/18:1(11Z))
2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) → CL(14:1(9Z)/14:1(9Z)/16:0/18:1(9Z))
2-MLCL(14:1(9Z)/14:1(9Z)/16:0/0:0) → CL(14:1(9Z)/14:1(9Z)/16:0/20:0)
KEGG ReactionsNot Available
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0550-9082512360-7e0189e59817489d8721JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-052r-6194551340-b15d389623b7faa0f063JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-08fr-6195612110-6a488ba634b6da1bf34eJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a70-2090010010-a1da7786815bd3615bcfJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-056r-4090010000-286ed8ec96ef5772cac5JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9061010000-a37042bd94c3cefcab3bJSpectraViewer
References
References:
  • Baile MG, Lu YW, Claypool SM. (2014). "The topology and regulation of cardiolipin biosynthesis and remodeling in yeast." Chem Phys Lipids. 2014 Apr;179:25-31. doi: 10.1016/j.chemphyslip.2013.10.008. Epub 2013 Nov 1.24184646
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI IDNot Available
HMDB IDNot Available
Pubchem Compound IDNot Available
Kegg IDNot Available
ChemSpider IDNot Available
FOODB IDNot Available
Wikipedia IDNot Available
BioCyc IDNot Available